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Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection

Multi-institutional Development and Validation of an Individualized Online Calculator for Early Mortality Risk After Hepatectomy Among Patients With Hepatocellular Carcinoma

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06621485
Enrollment
4966
Registered
2024-10-01
Start date
2024-02-15
Completion date
2024-03-31
Last updated
2024-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To Predict Early Post-hepatectomy Mortality for HCC

Keywords

Hepatocellular carcinoma, Hepatectomy, Survival, Morbidity, Futile surgery

Brief summary

Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma. The user-friendly tool with 6 preoperative predictors demonstrated excellent accuracy. The freely available calculator may help identify high-risk patients and reduce futile liver resection for hepatocellular carcinoma.

Interventions

None listed

Sponsors

Eastern Hepatobiliary Surgery Hospital of Shanghai
CollaboratorUNKNOWN
The First Hospital of Jilin University
CollaboratorOTHER
Mengchao Hepatobiliary Hospital
CollaboratorUNKNOWN
The Fourth Affiliated Hospital of Harbin Medical University
CollaboratorOTHER
Pu'er People's Hospital
CollaboratorUNKNOWN
Liuyang People's Hospital
CollaboratorUNKNOWN
Ziyang First People's Hospital
CollaboratorUNKNOWN
Qianfoshan Hospital
CollaboratorOTHER
First Affiliated Hospital of Harbin Medical University
CollaboratorOTHER
Fuyang people's hospital
CollaboratorOTHER
Beijing Tsinghua Chang Gung Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adults (age ≥18 years) who underwent curative-intent hepatectomy for newly diagnosed HCC. HCC diagnosis was confirmed histopathologically.

Exclusion criteria

Patients undergoing emergency hepatectomy for tumor rupture, as well as individuals with recurrent HCC, and those with missing survival data or less than 90 days of follow-up were excluded.

Design outcomes

Primary

MeasureTime frameDescription
90-day deathThe period starts from the day of the hepatectomy surgery and extends up to the 90th day post-surgery.90-day mortality after hepatectomy for HCC

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026