Mean Arterial Pressure
Conditions
Brief summary
This clinical trial aims to compare Patients who receive propranolol 1-2 mg to Patients who receive propranolol 1-2 mg in addition to magnesium sulphate infusion 10 mg/kg to see if IV magnesium can stability mean arterial blood pressure and heart rate in patients undergoing nasal surgeries as well as the quality of postoperative analgesia, degree of sedation mean arterial blood pressure and HR will be recorded intraoperative and Participants will be asked to rate the pain at the first, second, fourth, sixth and 24th postoperative hour using the VAS score. * Analgesic requirements: The time to first demand analgesia and the total amount of analgesia required in the 1st 24 will be recorded. * Sedation score: the degree of sedation will be assessed using the Ramsy sedation score
Detailed description
This prospective, randomized controlled clinical trial aims to establish the effect of magnesium sulphate during nasal surgery regarding deliberate hypotension, postoperative analgesia and sedation with minimal side effects. this study will be conducted in the plastic surgery and ENT operating rooms at ASUH 130 patients undergoing rhinoplasty or functional endoscopic sinus surgery (FESS) operation under general anaesthesia. patients will be allocated into 2 groups 65 patients each using a computer-generated randomization list. Group (P): Patients will receive propranolol 1-2 mg. Group (PM): Patients will receive propranolol 1-2 mg in addition to magnesium sulphate infusion 10 mg/kg. * ABP and HR are continuously monitored and will be recorded before the start of anaesthesia (T1), after intubation (T2), at skin incision (T3), at manipulation of nasal bones (T4), at extubation (T5), before discharge to PACU (T6), and after 30 min in PACU. * Surgical duration (time from skin incision till skin closure). * Extubation time (from the end of anaesthesia to extubation) * Modified Alderete score will be assessed and recorded every 5 minutes until discharge. Patients will be discharged upon achieving an Aldrete score of ≥ 9. * The time to discharge will be recorded. * VAS score for pain: * Analgesic requirements: The time to first demand analgesia and the total amount of analgesia required in the 1st 24 will be recorded. * Sedation score: the degree of sedation will be assessed using the Ramsy sedation score where all be recorded
Interventions
DRUGPatients will receive propranolol 1-2 mg.
Patients will receive propranolol 1-2 mg. prepared in a 10 ml syringe (100 ug/ml).
DRUGPatient receives magnesium sulphate
Magnesium sulphate 10%: 1g ampoule (10ml), will be prepared in a syringe pump to be given at a rate of 40 ml/hr . Another syringe of 10 ml 0.9% sodium chloride will be prepared to be given in group (P).
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing rhinoplasty or functional endoscopic sinus surgery (FESS) operation under general anesthesia * ASA I or II * Duration of surgery will be 1-2 hours
Exclusion criteria
* Hypertension, * Myasthenia gravis or other muscular disease, * Impaired kidney or liver functions, * History of drug or alcohol abuse, * History of antidepressant and calcium channel blocker use, * Mental retardation and hysterical patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mean arterial blood pressure | intraoperative | mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| analgesia | 24 hours postoperative | Visual analogue score |
Countries
Egypt
Outcome results
None listed