Alveolar Recruitment in Obese Patients in Major Gynaecological Cancer Surgery

The Effect of Alveolar Recruitment on Perioperative Outcomes in Obese Patients in Major Gynaecological Cancer Surgery: a Prospective Randomised Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06619626

Enrollment

Registered

2024-10-01

Start date

2024-01-01

Completion date

2024-11-30

Last updated

2024-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecologic Cancers

Keywords

gynecologic cancer surgery, alveolar recruitment strategy, positive end-expiratory pressure

Brief summary

In this study, the investigators planned to evaluate the effect of alveolar recruitment strategy primarily on postoperative pulmonary complications in obese patients undergoing lung protective ventilation in major open gynaeco-oncological surgeries. Our other aim was to evaluate perioperative haemodynamics, respiratory mechanics,inpatient length of stay.

Detailed description

In the gynaecological oncology clinic of our hospital, open major surgeries for endometrial or ovarian cancer are performed very frequently. In these surgeries, the abdomen is open to the operating theatre environment and the lithotomy and trendelenburg position may have negative consequences on the respiratory system in patients. Intraoperative lung protective ventilation strategies are recommended to reduce postoperative pulmonary complications. In the lung protective ventilation strategy, positive end-expiratory pressure is recommended in addition to 6-8 ml/kg tidal volume according to ideal body weight. In addition, alveolar recruitment strategy can be applied. For this purpose, the investigators planned to evaluate the effect of alveolar recruitment strategy on postoperative pulmonary complications in patients who underwent lung protective ventilation in major open gynaecooncological surgeries. Our secondary aim was to evaluate perioperative haemodynamics, respiratory mechanics, inpatient length of stay.

Interventions

DEVICEalveolar recruitment strategy applied group

the effect of alveolar recruitment strategy on the mechanical parameters of the patients

DRUGgroup without alveolar recruitment strategy

effect on mechanical parameters of patients without alveolar recruitment strategy

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with ASAII and III * BMI\>30 kg/m2 ,\<40 kg/m2 * Patients with an ARISCAT risk score of 26-44

Exclusion criteria

* Patients with an Assessment of Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) risk score \> 44 * BMI \> 40 kg/m2 patients

Design outcomes

Primary

Measure	Time frame	Description
postoperative pulmonary complications	24 hours postoperatively	Our primary aim was to compare the presence of postoperative pulmonary complications. The presence of these pulmonary complications will be compared between preoperative chest X-ray and postoperative day 1 X-ray imaging in patients with Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) risk score below 44.

Secondary

Measure	Time frame	Description
intraoperative haemodynamic parameters	intraoperatively	Our secondary aim was to evaluate intraoperative haemodynamic parameter(mean arterial pressure) in alveolar recruitment strategy in lung-protective ventilation.

Countries

Turkey (Türkiye)

Contacts

Primary ContactDuygu Akyol

dr.duyguaygun@gmail.com+905447616034

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026