Health Knowledge, Attitudes, Practice
Conditions
Keywords
Coenzyme Q10, Supplementation, Myokine, Exerkine, Cognition, Long-distance runners
Brief summary
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners. Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners? Participants will: Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
Interventions
DIETARY_SUPPLEMENTCoQ10 supplementation
Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.
DIETARY_SUPPLEMENTPlacebo supplementation
Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.
Sponsors
Gdansk University of Physical Education and Sport
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Intervention model description
A randomized, double-blind, placebo-controlled, cross-over study
Eligibility
Sex/Gender
MALE
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* training experienced for minimum 2 years * running training at least 2 times per week * Personal Best on 10k (\<50 minutes)
Exclusion criteria
* taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids) * injured in last 6 months to avoid n number reduction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test. | The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 | The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing. |
| Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation. | The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 | The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill | The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 | The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer |
Countries
Poland
Outcome results
None listed