Ovarian Cancer
Conditions
Brief summary
circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs \[8\], are involved in the regulation of various biological functions. They act by sponging off certain microRNAs (miRNAs) and play a role in the pathogenesis of many diseases, including cancers \[9-11\]. In addition, circRNAs are not com- monly degraded by RNA enzymes present in body flu- ids \[8\], and most of them possess expression specificity at the tissue, cell, and developmental stage level \[12,13\]. Thus, they can be ideal clinica
Detailed description
epithelial OC (EOC), the most common form of OC, accounts for 90% of all OC cases \[2\]. EOC has the highest mortality among all gynecologic tumors and poses a serious threat to women's life \[3\].herefore, early clinical diagnosis is crucial. Commonly used laboratory indicators for OC diagnosis
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
\- patients at South Egypt Cancer institute and Recently diagnosed ovarian cancer patients 2. Patients not went to surgery.
Exclusion criteria
* . Patients receive any anti-cancer therapy. 2. Patients diagnosed with other concomitante cancer or chronic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| role of circDENND4c in the diagnosis of ovarian cancer | baseline | by quality real time PCR we use the circDENND4c as a tumour marker for ovarian cancer |
Contacts
Primary ContactMarwa MamDouh Mohamed
Outcome results
None listed