Comparison of Autologous Quadriceps and Hamstring Tendon Grafts in Anterior Cruciate Ligament Reconstruction

A Prospective Comparison of Clinical and Radiological Maturation Outcomes of Autologous Quadriceps and Hamstring Tendon Grafts in Anterior Cruciate Ligament Reconstruction

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06617559

Enrollment

Registered

2024-09-27

Start date

2024-05-14

Completion date

2026-03-31

Last updated

2024-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cruciate Ligament Injuries, Athletic Injuries, Tendon Graft; Complications

Keywords

anterior cruciate ligament reconstruction, hamstring tendons, athletic injuries

Brief summary

With the recent technological advancements, the use of the quadriceps tendon with an all-inside technique has come to the forefront, and large-scale research has focused especially on quadriceps tendon grafts. Clinical study results have reported that the outcomes are similar to those of patellar tendon grafts and either equivalent or superior to hamstring tendon grafts. The aim of this study is the prospective comparison of the clinical and radiological outcomes of patients who underwent anterior cruciate ligament (ACL) reconstruction with autologous hamstring and quadriceps tendon grafts.

Interventions

PROCEDUREAnterior Cruciate Ligament Reconstruction with Quadriceps Autograft

The investigators will perform all-inside anterior cruciate ligament reconstruction using only the tendon portion of the quadriceps tendon (without bone fragments) in this group.

PROCEDUREAnterior Cruciate Ligament Reconstruction with Hamstring Autograft

The investigators will perform all-inside anterior cruciate ligament reconstruction using the hamstring tendon as a graft in this group.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Intervention model description

There are two standard autografts used for ACL reconstruction in the investigators' clinic: quadriceps and hamstring autografts. Patients will be randomly assigned to groups based on the order of their hospital admission. It is planned to have at least 25 patients in each group.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elite athletes * Amateur athletes * Anterior cruciate ligament injury

Exclusion criteria

* Revision surgery * Another ligament injury ( medial collateral ligament, lateral collateral ligament, etc.. ) * \> Grade-2 cartilage injury * Having previously undergone surgery on the same knee * \< 18 years age

Design outcomes

Primary

Measure	Time frame	Description
Autograft Maturation	12 months	Comparison of different autografts maturation on MRI images. The signal-to-noise quotient formula will be used to assess graft maturation. According to the method described by Chan and Yau, the difference between the signals of the ACL graft and the quadriceps tendon will be used to evaluate maturation by relating it to the background signal.
Stability of Knee	9 months	Pivot shift test

Secondary

Measure	Time frame	Description
Range of Motion	6 months	Measurement of knee flexion and extension degrees with a goniometer.
Muscle Strength	9 months	Measurement of quadriceps and hamstring muscle strength with Cybex test

Countries

Turkey (Türkiye)

Contacts

Primary ContactMuzaffer Agir, MD

muzafferagir@gmail.com+905543060011

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026