Healthy Individuals, Schizophrenia
Conditions
Brief summary
This study aims to explore the differences in autonomic nervous function and meridian energy between schizophrenia patients and healthy individuals. By understanding the meridian and organ conditions of individuals, the study aims to align with the traditional Chinese medicine (TCM) concept of treating disease before it arises and provide comprehensive care to patients, thereby improving the quality of care.
Detailed description
Data collection was conducted at a medical center in northern Taiwan. Sample size estimation was performed using G\*Power 3.1. A total of 50 patients with schizophrenia were assigned to the disease group, and 50 healthy individuals were assigned to the control group, with a total of 100 participants expected. Data collection included: personal demographic questionnaire, body constitution questionnaire (BCQ), WHOQOL-BREF (Taiwan version) for quality of life, brief psychiatric rating scale (BPRS), heart rate variability (HRV), meridian energy
Interventions
OTHERno intervention
no intervention
Sponsors
National Taiwan University Hospital
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Disease group： * Diagnosed with schizophrenia by a physician (ICD-10 code F20, such as F20.0, F20.1, F20.2, F20.3, F20.5, F20.89, or F20.9), with stable condition, and has not had any changes in medication dosage or admission to a psychiatric acute care unit in the past 3 months. * Aged between 18 and 65 years. * Able to understand, speak, read, and write Mandarin or Taiwanese. 2. Control group： * No history of chronic illness and no acute symptoms within the past month. * Aged between 18 and 65 years. * Able to understand, speak, read, and write Mandarin or Taiwanese.
Exclusion criteria
1. Disease group： * Individuals with cardiovascular conditions, severe neurological disorders (e.g., organic brain disorders, early-stage dementia or diagnosed dementia), or substance abuse issues. * Individuals who have used medications affecting the autonomic nervous system within the past month, such as mood stabilizers, antidepressants, angiotensin-converting enzyme inhibitors inhibitors, β-blockers, or antiarrhythmics. * Individuals with metallic implants that could affect heart rate variability. * Individuals with involuntary and uncontrollable body tremors. * Women currently menstruating. * Pregnant women. 2. Control group： * Individuals with cardiovascular conditions, severe neurological disorders (e.g., organic brain disorders, early-stage dementia or diagnosed dementia), or substance abuse issues. * Individuals who have used medications affecting the autonomic nervous system within the past month, such as psychiatric medications, angiotensin-converting enzyme inhibitors inhibitors, β-blockers, or antiarrhythmics . * Individuals with metallic implants that could affect heart rate variability. * Individuals with involuntary and uncontrollable body tremors. * Women currently menstruating. * Pregnant women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| meridian energy | This study is a cross-sectional study with a single follow-up. Participants who meet the inclusion criteria will be included in the study, with a recruitment period of one year. | Measuring the body energy under static balance conditions using principles of electromagnetic induction technology.The measurement items include:lung meridian (LU), large intestine meridian (LI), stomach meridian (ST), spleen meridian (SP), heart meridian (HT), small intestine meridian (SI), bladder meridian (BL), kidney meridian (KI), pericardium meridian (PC), triple burner meridian (SJ), gallbladder meridian (GB), liver meridian (LR) |
| heart rate variability | This study is a cross-sectional study with a single follow-up. Participants who meet the inclusion criteria will be included in the study, with a recruitment period of one year. | Assessing autonomic nervous system activity through the measurement of RR intervals. The measurement items include: the square root of the mean squared differences of successive NN intervals , NN50 count divided by the total number of all NN intervals, HRV triangular index, low frequency power, high frequency power, LF/HF Ratio, total power |
Countries
Taiwan
Contacts
Primary ContactYi-Min Pan
Outcome results
None listed