Hemophagocytic Syndrome
Conditions
Keywords
hemophagocytic syndrome screening system
Brief summary
Our three-step screening system uses commonly used clinical and laboratory parameters to effectively identify patients who may be at high risk of HLH, conduct etiology screening early for patients who meet the diagnostic criteria for HLH, and guide standardized treatment. Therefore, this study proposes to establish a highly accurate and convenient hemophagocytic early warning system to improve the early diagnosis of patients with hemophagocytic syndrome and identify suspected HLH patients early. Etiology screening is performed on patients who meet the diagnostic criteria for HLH, high-risk predisposing factors are identified, and precise treatment is guided, thereby improving the success rate of patient treatment and improving the quality of life.
Interventions
DRUGPatients diagnosed with HLH-94 should be treated as soon as possible
For some highly suspicious patients, after diagnosis, according to the patient's etiology, the treatment plan should be determined as soon as possible, such as lymphoma-related patients treated with hormones combined with etoposide, which can greatly improve the prognosis of patients
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Subjects must meet all of the following criteria: 1. Patients who meet the first step screening + have ≥ 3 abnormal screening indicators in the second step 2. Patients who meet the first step screening + have 2 abnormal screening indicators in the second step + patients with high-risk factors for HLH, such as history of lymphoma, EBV infection, autoimmune diseases, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The suspected patient was diagnosed with hemophagocytic syndrome after complete NK cell activity, triglyceride tests, etc. | Time forecasting:2 years |
Countries
China
Contacts
Primary ContactWei Sang, Doctor
Outcome results
None listed