Post Operative Delirium
Conditions
Brief summary
This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA). The study will compare the outcomes of patients receiving dexmedetomidine to those receiving a standard anesthetic or sedative, focusing on factors such as patient characteristics, surgical duration, and postoperative care. The research will explore the potential neuroprotective effects of dexmedetomidine and its ability to mitigate the risks associated with anesthesia and surgery in vulnerable elderly populations.
Interventions
DRUGDexmedetomidine Injection [Precedex]
Dexmedetomidine (Precedex, 100 µg/ml) was provided as an intravenous (IV) loading dose of 1 µg/kg over 10-min
Dexmedetomidine infusions were prepared to provide 0.5 µg/kg/h
DRUGNormal saline
loading dose of saline was injected 10-min before induction of anesthesia.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients with Severe chronic knee osteoarthritis inducing limitation of movement and required knee replacements; * Patients of American Society of Anesthesiologists Classification grades II-III; * Patients free of
Exclusion criteria
.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients reporting at least a 50% reduction of Postoperative Delirium (measured by Confusion Assessment Method, Delirium Index) post-Total knee arthroplasty under sevoflurane inhalational anesthesia. | 3 months |
Countries
Egypt
Outcome results
None listed