Frailty, Hip Fracture, Inflammatory Biomarkers
Conditions
Brief summary
We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.
Detailed description
Frailty (F) is a prevalent syndrome among elderly patient with hip fractures (HF) and has been linked to poor prognosis. Inflammatory biomarkers have been used as prognostic indexes in patients with HF. We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.
Interventions
None listed
Sponsors
University of Thessaly
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>65 years, ASA PS I-III, non- institutionalized, able to communicate patients
Exclusion criteria
* Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frailty status | preoperatively | Frailty will be categorized based on the validated Groningen Frailty Indicator (GFI) as non-frail (NF, score 0,1), pre-frail (PF, score 2, 3) and severe frail (SF, score \>4). |
| Inflammatory biomarkers | preoperatively | Upon admission and immediate before surgery upper limits of white blood cells (WBC) within normal range (WBC \>8 10\^3/μL), NLR (neutrophils/lymphocytes), PLR (platelets/lymphocytes), CRP (C-reactive protein) and CLR (CRP/lymphocytes), will be recorded. |
Countries
Greece
Contacts
CONTACTEleni Arnaoutoglou, Professor
CONTACTMaria Ntalouka, MD, PhD, MSc
STUDY_CHAIREleni Arnaoutoglou, Professor
University of Thessaly
Outcome results
None listed