Aging, Biological, Anti-Aging, Dietary Supplement, DNA Methylation, Longevity, Metabolic Health, Physical Activity, Sport, Taurine
Conditions
Keywords
taurine, biological aging, metabolic health, anti-aging, epigenetic clock, aging, physical activity, cognition, Cellular Senescence, hallmarks of aging, humans, Dietary Supplements, longevity, Taurine Deficiency, Taurine Level, aging metabolism, longevity physiology, drug effects, DNA-methylation, aging ptoeomics, DNA methylation, taurine microbiome, taurine gut micorbiota, taurine cognition, taurine sport, taurine DNA methylation, nutritional medicine, sport biology, taurine physical fitness, taurine physical acitvity, taurine sport biology, taurine muscle strength, taurine pwc 130, Taurine HOMA IR, taurine mental health, taurine human aging, taurine cardiometabolic risk, taurine cardiometabolic health, taurine blood pressure, taurine fasting glucose, taurine inflammation, taurine biological aging
Brief summary
The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is: • Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect. Participants will: * Take 4g of taurine or a placebo every day for 6 months * Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks
Detailed description
Measurements performed during study visits: * Biological age estimate via proteome analysis * Organ age estimates (proteomics) * DNA methylation * Inflammatory biomarkers (CRP, cytokines) * Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI * Physical fitness (hand grip strength, leg extensor strength, PWC130) * Resting energy expenditure * Cognitive function via questionnaire * Quality of life * Heart rate variability * Physical activity, nutrition
Interventions
DIETARY_SUPPLEMENT4g of taurine daily
Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months
DIETARY_SUPPLEMENTPlacebo
Controll group (4g of placebo/day): 2g of placebo (4 capsules, 500mg each) in the morning and 2g of placebo (4 capsules, 500mg each) in the evening for 6 months
Sponsors
Stanford University
Rutgers University
Universitaet Innsbruck
LMU Klinikum
Technical University of Munich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* women or men * Age 55 - 75 * BMI 22 - 30 kg/m² * written consent
Exclusion criteria
* Acute or chronic inflammation (e.g. flu infection) * Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renal insufficiency) * Myocardial infarction or stroke in the previous 6 months * Psychiatric disorder, including depression or dementia * Weight change of ≥ 5 kg in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline in Biological Age At 6 Months (Proteome Analysis) | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be determined using a plasma proteome analysis and established machine learning models based on plasma and urine samples. This will also include an analysis of organ-specific aging. |
| Change From Baseline in Biological Age At 6 Months (DNA Methylation) | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be estimated by assessing DNA methylation patterns (epigenetic clock) from plasma, urine, and oral mucosa samples. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline In Handgrip Strength (kg) at 6 Months | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | Measurement of handgrip strength in kilograms and Newtons in the dominant hand using Jamar Hydraulic Hand Dynamometer. |
| Change From Baseline In Cognitive Functions at 6 Months | pre-intervention (at time point 0) and post-intervention (after 24 weeks) | Does a 6-month supplementation with 4 g of taurine daily influence parameters of mental health? Methods of measurement: MoCA (Montreal Cognitive Assessment) |
| Change From Baseline In Isometric Leg Extensor Strength For Each Leg At 6 Months | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | Measurement of leg extensor strength using a force transducer connected to the back of a chair and an ankle loop, as well as force recording software. The maximum force (N) will be multiplied with the distance from knee joint to the middle of the loop (in metres) to calculate the torque in Newton-metres (Nm) for each leg. |
| Change From Baseline In Physical Working Capacity (PWC130) At 6 Months | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | Measurement of heart rate (bpm) on the Corvial ergometer while increasing power manually by 25 W every 2 minutes. The endpoint is the power in Watts at the stage where heart rate of 130bpm is reached. |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | pre-intervention (at time point 0) and post-intervention (at 24 weeks) | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: fasting blood glucose in mg/dL |
Countries
Germany
Outcome results
None listed