Cartilage Degeneration, Weightlessness
Conditions
Brief summary
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
Detailed description
A total of 26 subjects were recruited for a 60-day period of head-down bed rest (HDBR). The bed rest position is a 6° downward tilt of the head, and all daily activities are performed in this position. We will perform functional MRI scans of the right knee joint using T2 mapping sequences to assess tissue composition and water content before and after HDBR. Functional assessments, including the Y-Balance Test and International Knee Documentation Committee (IKDC) scores, were performed pre-HDBR and post-HDBR.We will divide each participant's knee cartilage into 18 regions and measured T2 values according to the whole organ magnetic resonance imaging score (WORMS) partitioning method.
Interventions
BEHAVIORAL60-day-6° head-down bed rest
Throughout the bed rest period, subjects carried out all activities of daily living-eating, voiding, recreation, and testing
Sponsors
Peking University Third Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* (1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg/m²; (4) good general health status.
Exclusion criteria
* (1) history of alcoholism; (2) smoking ≥5 cigarettes/day in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T2 mapping | three days before the HDBR started and three days after the HDBR ended | metabolic and microstructural changes within the articular cartilage matrix components can be assessed, reflecting collagen fiber structure integrity and water content within the tissue |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Y-balance test | three days before the HDBR started and three days after the HDBR ended | can comprehensively evaluate an individual's joint range of motion, lower limb strength, sense of balance, and neuromuscular control, as well as the postural control and dynamic stability of lower limbs. |
| International Knee Documentation Committee (IKDC) scores | three days before the HDBR started and three days after the HDBR ended | reflects the highest level of activity that an individual is able to perform. |
Countries
China
Contacts
Primary ContactJianquan Wang, M.D.
Outcome results
None listed