Caffeine and Resistance Exercise, CYP1A2 Polymorphism
Conditions
Brief summary
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the acute effects of caffeine on this type of exercise. Objectives: The present study aims to analyze the effects of acute caffeine intake on muscular strength, power, and endurance performance according to CYP1A2 polymorphism in men and women.
Interventions
DIETARY_SUPPLEMENTCaffeine
Acute caffeine intake (3 mg/kg)
DIETARY_SUPPLEMENTPlacebo
Placebo (3 mg/kg maltodextrin)
Sponsors
Alberto Pérez-López
University of Alcala
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between ≥ 18 and ≤ 35 years. * Body mass index (BMI) lower than 25 kg/m². * Physically active subjects (≥150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests.
Exclusion criteria
* History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cyp1a2 polymorphism | Before the beginning of the trial | Using saliva sample and PCR |
| Mean velocity at different %1RM | Through study completion, an average of 2 weeks | Measuring bar mean velocity desplacement during bench press and back squat exercises. |
| Peak velocity at different %1RM | Through study completion, an average of 2 weeks | Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises. |
| Mean power output at different %1RM | Through study completion, an average of 2 weeks | Measuring during bench press and back squat exercises. |
| Peak power output and time to reach peak power output at different %1RM | Through study completion, an average of 2 weeks | Measuring during bench press and back squat exercises. |
| Number of repetitions performed in 1 set at 65%1RM until task failure | Through study completion, an average of 2 weeks | In bench press and back squat exercises |
| Bar velocity deplacement performed in 1 set at 65%1RM until task failure | Through study completion, an average of 2 weeks | In bench press and back squat exercises |
| Power output generated in 1 set at 65%1RM until task failure | Through study completion, an average of 2 weeks | In bench press and back squat exercise |
| Maximal Fat Oxidation Rate (MFO) | Through study completion, an average of 2 weeks | g/min (MFO) using a metabolic chart. |
| Resting Metabolic Rate (RMR) | Through study completion, an average of 2 weeks | Kcal at rest (RMR) using a metabolic chart. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mood state (tension, depression, anger, vigor, fatigue and confusion) | Through study completion, an average of 2 weeks | Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question: How do you feel at this moment? to assess six scales: tension, depression, anger, vigor, fatigue and confusion. |
| Adverse effects | Through study completion, an average of 2 weeks | perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort |
| handgrip and isometric mid-thigh pull tests | Through study completion, an average of 2 weeks | N generated |
| Vertical Jump (cm) | Through study completion, an average of 2 weeks | — |
| Vertical Jump (power) | Through study completion, an average of 2 weeks | — |
Countries
Spain
Outcome results
None listed