Obstructive Hypertrophic Cardiomyopathy (oHCM)
Conditions
Keywords
left ventricular mass index, all-cause death, survival, obstructive hypertrophic cardiomyopathy, septal myectomy
Brief summary
In this study, we aimed to analyze the association between left ventricular mass index and clinical outcomes to provide the potential indicator for worse survival.
Detailed description
This retrospective study aimed to determine the prognostic value of left ventricular mass index in predicting clinical outcomes, including all-cause death, new-onset or recurrent atrial fibrillation, and a composite endpoint of all-cause death, heart failure,permanent pacemaker implantation, new-onset or recurrent atrial fibrillation, and stroke.
Interventions
OTHERPatients had a higher left ventricular mass index or not （the exact value is determined by the cut-off value for the clinical outcomes)
Patients were grouped by the cutoff value of left ventricular mass index (LVMI) for all cause death, and the Maximally Selected Rank Statistics method was used to determine the optimal cutoff point of LVMI for death.
Sponsors
Changrong Nie
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
(1) Difficulty in relieving symptoms with medication or recurrent syncope. (2) Left ventricular outflow tract (LVOT) pressure gradient ≥ 50 mmHg at rest or with provocation and the maximum thickness of the septum is ≧ 15 mm.
Exclusion criteria
* (1) Combined right ventricular outflow tract obstruction requiring right ventricular outflow tract dissection. (2) Combined mitral or aortic valve organic lesions requiring valve replacement surgery. (3) Apical ventricular aneurysm formation requiring ventriculotomy. (4) Previous septal reduction therapy, including alcohol ablation or septal myectomy. (5) patients did not undergo cardiac magnetic resonance examination.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause death | One month after discharge | Any death observed one month after discharge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| composite endpoint | One month after discharge | Composite endpoint included all-cause death, and nonfatal adverse events, with nonfatal adverse events defined as rehospitalization for heart failure, permanent pacemaker implantation, new-onset or recurrent atrial fibrillation, and stroke. |
Countries
China
Outcome results
None listed