Outcome of Cardiac Arrest Patients Following Guidelines Implementation Over the Years

Implementation of the New Guidelines on the Management of Patients Resuscitated From Cardiac Arrest and Impact on Survival: a Multicenter Retrospective Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06608771

Acronym

IMPACT-ACC

Enrollment

693

Registered

2024-09-23

Start date

2024-07-26

Completion date

2026-03-30

Last updated

2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

Out-Of-Hospital Cardiac Arrest, In-Hospital Cardiac Arrest, Guidelines Implementation, Resuscitation

Brief summary

The study aims to evaluate the level of local implementation of the new interventions introduced by the guidelines for post-cardiac arrest management and their impact on the survival of patients resuscitated from cardiac arrest and admitted to intensive care over a 14-year period. During this time period, the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) introduced three new guidelines for post-cardiac arrest management, each five years apart: the 2010, 2015, and 2021 guidelines.

Detailed description

This study is a retrospective multicenter cohort observational study (two centers involved: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Fondazione IRCCS San Gerardo dei Tintori). All patients admitted to the Intensive Care Units (ICU) of the hospitals involved in the study from January 1, 2011, to May 30, 2024, following cardiac arrest of any etiology, who meet the inclusion and exclusion criteria, will be enrolled.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients resuscitated from cardiac arrest and admitted to intensive care unit * Age ≥ 18 years * Out-of-hospital and in-hospital cardiac arrest * Cardiac arrest of any etiology

Exclusion criteria

* Pediatric patients (\<18 years) * Patients not admitted to one of the aforementioned intensive care units.

Design outcomes

Primary

Measure	Time frame	Description
Intensive Care Unit (ICU) Survival	From cardiac arrest date to ICU discharge or death, up to 90 days	To evaluate ICU survival for patients resuscitated from cardiac arrest
Neurological recovery at ICU discharge	From cardiac arrest date to ICU discharge or death, up to 90 days	ICU Survival with Cerebral Performance Category (CPC) score of 1 or 2

Secondary

Measure	Time frame	Description
Hospital discharge status	From cardiac arrest date to hospital discharge or death, up to 180 days	To evaluate hospital survival for patients resuscitated from cardiac arrest

Countries

Italy

Contacts

Primary ContactGiuseppe Ristagno, MD, PhD

giuseppe.ristagno@unimi.it+390255033258

Backup ContactMauro Panigada, MD

mauro.panigada@policlinico.mi.it+390255033258

Outcome results