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Paraesternal Blockade and Lactate Serum Levels in Patients with Cardiac Surgery.

Association Between the Application of Parasternal Blockade and Serum Lactate Level in Trans and Post-anesthetic Stages in Cardiac Surgery.

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06608290
Enrollment
86
Registered
2024-09-23
Start date
2022-01-01
Completion date
2024-09-02
Last updated
2024-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Parasternal Block, Serum Lactate

Keywords

Parasternal block, cardiac surgery, serum lactate, cardiopulmonary bypass, cardiovascular surgery post-surgical unit

Brief summary

Parasternal blockade has been related to a reduction of the postoperative inflammatory response, by inhibition of the stress response, leading to a better prognosis. Increased lactate level is a useful parameter in identifying patients at risk of postoperative morbidity and mortality. The objective was to evaluate the association between parasternal blockade and serum lactate level in patients undergoing cardiac surgery, both trans- and post-anesthesia. 86 patients between 60-70 years of age participated. An association was found between the application of parasternal blockade in cardiac surgery and the presence of lower trans and postanesthetic serum lactate levels.

Detailed description

An analytical cross-sectional study in adult patients who underwent elective cardiac surgery. A total sample of 86 patients was obtained, 43 in the case group and 43 in the control group. Adult patients older than 18 years, of either sex, with ASA II-III, patients who underwent cardiac surgery with median sternotomy and use of cardiopulmonary bypass were included.

Interventions

Administration of parasternal block with ropivacaine, bilaterally at the sternum before the start of surgery.

DIAGNOSTIC_TESTLactate serum level

Blood samples were taken to identify serum lactate levels greater than 2 mmol/l and those that remained below this limit.

Sponsors

Instituto Mexicano del Seguro Social
Lead SponsorOTHER_GOV

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Patients were classified as a group of cases with parasternal blockade and as a group of controls without parasternal blockade, with a ratio of cases to controls of 1:1. In the case-control groups, patients with elevated serum lactate levels greater than 2 mmol/L and those who remained below this limit were identified.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patients over 18 years of age * Either sex * ASA II-IV * Patients who underwent cardiac surgery with median sternotomy and use of cardiopulmonary bypass. Elimination criteria \- Patients with pre-existing conditions that could independently affect serum lactate levels

Design outcomes

Primary

MeasureTime frameDescription
Lactate serum levels24 HoursBlood samples were taken to identify serum lactate levels greater than 2 mmol/l and those that remained below this limit.

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026