Infection Wound, Antibiotic Resistant Infection
Conditions
Keywords
antibiotic, prophylaxis, cholecystectomy, postoperative
Brief summary
Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.
Interventions
DRUGIV antibiotic
Parenteral prophylactic antibiotics (cefazolin), 1st dose at the time of induction of anesthesia, 2nd dose after 12hs from the surgery.
DRUGOral antibiotic
Parenteral prophylactic antibiotic (cefazolin), dose at the time of induction of anesthesia and then oral antibiotic for five days postoperative.
Sponsors
Minia University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (aged above 18 years) undergoing laparoscopic cholecystectomy.
Exclusion criteria
* patients with comorbidities (Diabetes, malignancies, Immunosuppressed). Lost of follow-up. Patients received antibiotics within 72 hr before admission. Complicated cases involved, gangrenous and perforated cholecystitis and abscess.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgical site infection | 4 weeks | DSSI = deep surgical site infection; SSSI = superficial surgical site infection. |
Secondary
| Measure | Time frame |
|---|---|
| Fever | 4 weeks |
| Length of the hospital stay | 4 weeks |
| Hematoma and Seroma formation | 4 weeks |
Countries
Egypt
Contacts
Primary ContactAsmaa A Elsayed
Outcome results
None listed