Healthy
Conditions
Keywords
Lamb, Omega-3, Fatty acids, Plasma, Plasma phospholipids
Brief summary
This study will investigate the impact of consuming grass-finished lamb meat on blood omega-3 PUFAs and cardiovascular risk factors compared to concentrate-finished lamb meat. Healthy volunteers will consume three portions of lamb meat/week from a grass-finished meat treatment or a concentrate-finished meat treatment for four weeks. Blood samples will be taken at weeks zero and four. The primary outcome is to assess difference in change in omega-3 PUFA concentration in plasma and platelets between treatment groups. The secondary outcome is to assess between groups differences in change in cardiovascular disease risk factors including blood pressure, BMI and lipids among healthy individuals.
Interventions
OTHERGrass fed lamb
This study investigated the impact of consuming grass finished lamb on total blood plasma and blood plasma phospholipids (PL) FA and on cardiovascular risk factors, including heart rate, blood pressure (BP), HDL-cholesterol, LDL-cholesterol, and TAG cholesterol, in humans.
Sponsors
Agri-Food and Biosciences Institute
Queen's University, Belfast
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Describe it was the participant
Intervention model description
Describe parallel arms
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male and female volunteers aged between 18-64 years old.
Exclusion criteria
* Participants with a BMI of \<18.5 km/m² and greater than \>35 km/m². * Participants who take prescribed medication, including statins to reduce LDL cholesterol, and any form of dietary supplements (excluding vitamin D). * People who smoke. * Participants who consume more than two portions of fish per month.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatty acid (%) change in blood plasma between treatments | Week 0 and week 4 | Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma response in healthy volunteers |
| Fatty acid change (%) in blood plasma phospholipids between treatments | Week 0 and week 4 | Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma phospholipid response in healthy volunteers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in weight (kg) in participants between treatments | Week 0 and week 4 | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight among healthy volunteers |
| Change in Body Mass Index (BMI) in participants between treatments - calculated by dividing weight (kg) by height in meters squared | Week 0 and week 4 | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight and BMI response in healthy volunteers |
| Cholesterol | Week 0 and week 4 | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on total cholesterol, LDL, HDL and TAG response in healthy volunteers |
| Blood pressure (diastolic and systolic) | Week 0 and week 4 | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood pressure (diastolic and systolic) response in healthy volunteers |
Countries
United Kingdom
Outcome results
None listed