Aging
Conditions
Keywords
Aging, Creatine, Resistance-Bands, Muscle, Strength
Brief summary
The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance). A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).
Detailed description
Resistance-band training is safe, conveient, easy-to-use, eliminates potential barriers to exercise participation (i.e., lack of transportation to and from commercial training facilities) and results in high exercise compliance and adherence. Further, resistance-band training results in similar improvements in muscle performance and functional ability compared to traditional resistance-type training using free-weights and machines. Creatine is a naturally occurring nitrogen-containing compound produced in the body in the liver and brain and can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products. Evidence-based research shows that creatine supplementation, when ingested during a resistance exercise training program, improves measures of lean mass and muscle growth, muscle performance and functional ability. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.
Interventions
DIETARY_SUPPLEMENTCreatine Bolus 5
(Serving 1: 5 grams of creatine + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).
DIETARY_SUPPLEMENTCreatine Bolus 3
(Serving 1: 3 grams of creatine + 5 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).
DIETARY_SUPPLEMENTCreatine Intermittent 5
(Serving 1: 2.5 grams of creatine + 5.5 grams of placebo in the morning, Serving 2: 2.5 grams of creatine + 5.5 grams of placebo at least 6 hours after Serving 1).
DIETARY_SUPPLEMENTPlacebo
(Serving: 8 grams of placebo in the morning; Servings 2: 8 grams of placebo at least 6 hours after Serving 1).
Sponsors
Iovate Health Sciences International Inc
University of Regina
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* if you are 50 years of age and older * if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.
Exclusion criteria
* if you have taken creatine supplements within 30 days prior to the start of the study * if you have pre-existing allergies to the placebo (corn-starch maltodextrin).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Whole-body lean mass (kg) | baseline, week 16 | Bioelectrical impedance analysis |
| Muscle Hypertrophy (cm) | baseline, week 16 | B-mode ultrasound |
| Strength (kg) | baseline, week 16 | 1-repetition maximum leg press and chest press |
| Endurance (number of repetitions to fatigue) | baseline, week 16 | Leg press and chest press |
| Power (feet) | baseline, week 16 | medicine ball throw |
| Balance (Centre of Pressure) | baseline, week 16 | Force Plate |
| Gait Speed (meters) | baseline, week 16 | Walking distance |
Countries
Canada
Contacts
Primary ContactDarren Candow
Outcome results
None listed