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Reproducibility of Acute Caffeine Effect

Reproducibility of the Acute Effect of Caffeine on Energy Metabolism and Muscular Strength, Power and Endurance Performance

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06606639
Enrollment
48
Registered
2024-09-23
Start date
2024-01-08
Completion date
2024-05-22
Last updated
2025-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caffeine and Resistance Exercise

Brief summary

Introduction: Various studies have evaluated and verified the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, all experimental investigations designed so far have been based on the comparison of the "caffeine" and "placebo" conditions in a single trial, not considering the reproducibility and variability of caffeine in multiple trials. Objectives: The present study aims to evaluate the reproducibility and replicability of the acute effect of caffeine intake on energy metabolism and the muscular production of force, power and endurance, according to sex (men vs women) and type of exercise ( bench press vs squat).

Interventions

DIETARY_SUPPLEMENTCaffeine

acute caffeine intake (3 mg/kg)

DIETARY_SUPPLEMENTPlacebo

Acute placebo intake (3 mg/kg of maltodextrin)

Sponsors

University of Alcala
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)

Masking description

Statistician

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Age between ≥ 18 and ≤ 35 years. * Body Mass Index (BMI) < 25 kg/m². * Resistance-trained individuals (> 2 years of structured trained). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising. * Participants must be able to perform the tests described in the following section.

Exclusion criteria

* History of neuromuscular diseases, heart diseases, or diseases that may affect liver or muscle metabolism. * Use of drugs, other stimulants or sport supplements that interfere with the the study dietary supplement. * Sedentary habits (<150 min/week of moderate exercise). * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise during the 48 hours prior to the tests. * Failure to replicate the same food intake on the two days of the experiments. * Consuming caffeine or any other stimulant after 6 pm the day before the training or tests, to avoid headaches, discomfort, or lethargy among regular caffeine consumers.

Design outcomes

Primary

MeasureTime frameDescription
Maximal Fat Oxidation Rate (MFO)Through study completion, an average of 4 weeksg/min (MFO) using a metabolic chart.
Mean power output at different %1RMThrough study completion, an average of 4 weeksMeasuring during bench press and back squat exercises.
Peak power output and time to reach peak power output at different %1RMThrough study completion, an average of 4 weeksMeasuring during bench press and back squat exercises.
Number of repetitions performed in 1 set at 65%1RM until task failureThrough study completion, an average of 4 weeksIn bench press and back squat exercises
Bar velocity deplacement performed in 1 set at 65%1RM until task failureThrough study completion, an average of 4 weeksIn bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failureThrough study completion, an average of 4 weeksIn bench press and back squat exercise
Resting Metabolic Rate (RMR)Through study completion, an average of 4 weeksKcal at rest measuring (RMR) using a metabolic chart.
Mean velocity at different %1RMThrough study completion, an average of 4 weeksMeasuring bar mean velocity desplacement during bench press and back squat exercises.
Peak velocity at different %1RMThrough study completion, an average of 4 weeksMeasuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

Secondary

MeasureTime frameDescription
Physical activity (METs-min/wk)Through study completion, an average of 4 weeksUsing IPAQ
Mood stateThrough study completion, an average of 4 weeksMood. Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.
Adverse effectsThrough study completion, an average of 4 weeksAdverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort.
Fat massThrough study completion, an average of 4 weeksUsing electrical bioimpedance (kg and % of body mass)
Fat-free massThrough study completion, an average of 4 weeksUsing electrical bioimpedance (kg and % of body mass)
Dietary (g/kg of macronutrients)Through study completion, an average of 4 weeksUsing 24-total recall

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026