Post Partum Hemorrhage
Conditions
Brief summary
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality. Globally, it is responsible for 25% of all pregnancy-related deaths. PPH is unpredictable and may occur in the absence of risk factors. Tranexamic acid is an antifibrinolytic proven to reduce blood loss and transfusion requirements for various surgeries. This study aims to explore the effectiveness of tranexamic acid as an adjunct to other uterotonics before the Caesarian Section.
Interventions
DRUGTranexamic acid injection
All women recruited to Group A will receive tranexamic acid 1 gram in 100 ml Normal Saline as intravenous infusion 10 minutes before the skin incision.
DRUGPlacebo
All women recruited to Group B will receive 100 ml Normal Saline as intravenous infusion 10 minutes before the skin incision.
Sponsors
Aligarh Muslim University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. The women undergoing cesarean delivery (both elective and emergency) during the study period. 2. Willing to participate in the study after understanding the concept.
Exclusion criteria
1. Critically ill patient. 2. Not willing to give consent to participate in the study 3. Cases diagnosed with a ruptured uterus or undergoing caesarian hysterectomy during operation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative blood loss | Amount of blood loss from starting from surgical incision till 24 hours post caesarean section. | The primary aim of the trial is to investigate the effect of tranexamic acid on peri and post- operative blood loss during caesarean section |
Countries
India
Contacts
Primary ContactMUAZZAM HASAN, MD
Outcome results
None listed