Evaluation of Updated Procedure for Management of Refractory Out-of-hospital Cardiac Arrests

Evaluation of the Updated Procedure for the Management of Refractory Out-of-hospital Cardiac Arrests with SAMU 54 : the Revised ACEP Protocol in 02/2024

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06603649

Acronym

ACEP-V2

Enrollment

150

Registered

2024-09-19

Start date

2024-10-01

Completion date

2030-12-31

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest, Out-Of-Hospital

Brief summary

ECPR is a technique that has been rapidly developed in many cardiac arrest specialized centers In 2013, a specific management protocol was developed for patients in refractory out-of-hospital cardiac arrest around Nancy, France. To select patients with the best prognosis, the inclusion criteria defined were strict. This led to an over-selection of patients and a significant reduction in the number of eligible patients. A balance needed to be struck between over-selecting patients and maintaining the expertise of medical and paramedical teams in the field. In addition, it has also been shown that ECPR also increases the number of organs and transplants. In February 2024, the criteria for inclusion in the protocol were redefined to include any witnessed non-traumatic cardiac arrest, whatever the initial rhythm. This simplification should enable more patients to be included in the procedure. The aim of the study is to assess the patient's outcome

Interventions

OTHERECPR for out-of-hospital cardiac arrest

Patient with out-of-hospital cardiac arrest enrolled in the ECPR protocol

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Out-of-hospital cardiac arrest * enrolled in the ECPR program * 18 years old or more * Low-flow estimated \<60minutes

Exclusion criteria

* traumatic cardiac arrest * major comorbidities

Design outcomes

Primary

Measure	Time frame	Description
Survival	90 days after cardiac arrest	Survival rate of patients enrolled in the protocol

Secondary

Measure	Time frame	Description
Delays	From event to implementation of ECMO, in minutes, Up to 180 minutes	Delay between cardiac arrest and ECPR implementation
Neurological outcome	30 days and 90 days after cardiac arrest	Evaluation of neurological outcome of survivors after cardiac arrest using the Rankin score

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026