Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06603207

Acronym

RAPD-MR

Enrollment

220000

Registered

2024-09-19

Start date

2024-10-01

Completion date

2024-12-01

Last updated

2024-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Rheumatoid Arthritis

Keywords

Mendelian Randomization, Genome-Wide Association Study (GWAS), Inflammatory Diseases, Genetic Risk Factors, SNP (Single Nucleotide Polymorphism)

Brief summary

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Detailed description

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Participants included in the genome-wide association study (GWAS) database. * Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

Exclusion criteria

* Individuals without complete genotypic data or those with missing critical phenotypic information.

Design outcomes

Primary

Measure	Time frame	Description
Causal Association Between Rheumatoid Arthritis and Periodontitis	Data collected from 2023 to 2024.	This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.

Secondary

Measure	Time frame	Description
Analysis of Genetic Pleiotropy and Confounders	2023 to 2024	Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.

Outcome results