Binge-Eating Disorder, Bulimia Nervosa, Eating Disorders
Conditions
Keywords
exercise, eating disorders
Brief summary
This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.
Interventions
BEHAVIORALRest
Participants will eat breakfast but abstain from exercise
BEHAVIORALFed Exercise
Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max.
BEHAVIORALFasted Exercise
Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.
Sponsors
Ohio University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Engage in loss of control eating at least 12 times in the last three months * Clinically significant eating disorder-related impairment (CIA \> 15) * Minimum VO2max of 50th percentile for age and sex assigned at birth * Be willing to eat study-provided foods * Likes chocolate (at least 6/10 on 10 point scale)
Exclusion criteria
* BMI \< 18.5 kgm/2 * Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease) * Recent pregnancy or breastfeeding (prior 6 months) * Relevant food allergies (e.g., wheat, chocolate) * Specific phobia, blood-injection-injury type * Medical condition that precludes safe participation in exercise (e.g., stress fracture) * Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relative Energy Intake | Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise) | Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lactate | 30 minutes, pre-post exercise (or rest) | Lactate values |
| Acylated ghrelin | Immediately prior to lunch | Acylated ghrelin |
| Self-reported binge eating | 24 and 48 hours after exercise/rest study visit | Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely": "While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being present |
| Food reward value | Approximately 3:30 pm day of study visit | Number of trials according to task developed by Bodell and Keel 2015 |
Countries
United States
Outcome results
None listed