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Neurobic Exercise Program on Cognitive Abilities

Effects of Neurobic Exercise Program on Cognitive Abilities Among Older Adults With Mild Cognitive Impairment. A Randomised Controlled Trial.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06601751
Enrollment
44
Registered
2024-09-19
Start date
2024-09-22
Completion date
2025-06-25
Last updated
2025-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment

Keywords

Cognitive impairment, Neurobic exercise, Memory, ADL

Brief summary

This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.

Detailed description

MCI is a condition marked by a noticeable decline in cognitive functions, it is often considered a precursor to more severe forms of dementia, making early intervention crucial. Neurobic exercises are designed to stimulate the brain through multiple senses and to create a novel thinking pattern. These exercises might include activities involving sight, smell, touch, taste, and hearing, structured over six weeks to challenge the brain with non-routine tasks that promote creative thinking and memory retention. Neurobic exercise aims to maintain strength, flexibility, and mental health as you age. However, most research has focused on older, healthy individuals or those with chronic conditions. Studies on elderly persons with MCI are rare, and there are limited studies on the long-term effects of improved memory function. This research aims to investigate the significance of a neurobic exercise program on cognitive abilities in older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life. The findings will give insight to physiotherapists and multidisciplinary teams to improve memory retention, delay brain deterioration, and promote memory health and quality of life, making the intervention program a valuable guide.

Interventions

OTHERNeurobic Exercise Program

6 weeks to improve cognitive function, memory and overall brain health by introducing non-routine activities that require participants to utilise their multiple senses and remember sequences and patterns. Each activity would be performed 2-3 times/ session, for recalling the observation period set at 1 minute and at the end of the 9th week, the memory retention effect will be measured.

OTHERTraditional Brain Exercise

activities like calculation or memory games. These exercises will be conducted in 2 days/week for 60-minute sessions in 6 weeks. The memory retention effect will be measured at the end of the 9th week. It is intended to be the baseline for comparing the effectiveness of a neurobic exercise program.

Sponsors

Riphah International University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Older adults above 60 * Both male and female. * Scored \<24 on the Montreal Cognitive Assessment (MoCA). * Scored \>12 on the Modified Barthel ADL index (BAI). * Ability to write and read as well as communicate well, willingness to participate in the study throughout the program

Exclusion criteria

* Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment. * Older adults with a history of allergies to the food or flowers used in the activities.

Design outcomes

Primary

MeasureTime frameDescription
MOCA (Montreal Cognitive Assessment)9 weeksThe MOCA is a popular screening tool used to determine if cognitive impairment is present. It takes approximately ten minutes to complete. It evaluates visuospatial skills, attention, language, abstract reasoning, delayed recall, executive function, and orientation. MoCA is scored out of 30. A cut-off score of 26 signifies mild cognitive impairment.
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)9 weeksIt is used to measure subjective memory. This test measures the informant's perception of the older person's cognitive decline. Older adults are required to compare their performance today with their performance ten years ago. Informants were asked to indicate the change on a 16-item scale from 1 (much improved) to 5 (much worse). The cut-off scores were based on the total score divided by the number of questions (average item score range 1- 5). Lower scores indicated better subjective memory performance.
Common Object Memory Test (COMT)9 weeksIt is used to measure objective memory. The COMT was designed to assess age related memory impairments in individuals with various educational, language, and cultural backgrounds. It included repeated presentations of colour photographs containing 10 common objects (button, chair, clock, comb, cup, key, knife, leaf, scissors and umbrella) and multiple opportunities for participants to recall and recognise the original list. The total COMT scores were summed across these three steps, and the possible range was 0-90. Higher scores indicated better objective memory performance.

Secondary

MeasureTime frameDescription
Modified Barthel ADL Index (BAI)9 weeksThe Barthel Index for Activities of Daily Living is an ordinal scale used to measure a person's ability to perform ten common daily activities, including feeding, bathing, grooming, dressing, bowel and bladder control, toilet use, transfers (bed-to-chair), mobilityon level surfaces, and stair negotiation. A modified version by Collin and Wade uses a three-point scoring system (0 = unable, 1 = needs assistance, 2 = independent) with a total score ranging from 0 to 20. The assessment takes 2-5 minutes to complete.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026