Hopeless Teeth
Conditions
Keywords
dental implant, Erythropoietin, Xenograft
Brief summary
The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone
Detailed description
PICO: Population: Patients with non-restorable tooth in anterior maxilla with thin buccal bone (less than 1mm) Intervention: Immediate implant placement with Xenograft mixed with Erythropoietin. Control: Immediate implant placement with Xenograft alone.
Interventions
COMBINATION_PRODUCTErythropoietin (EPO) with xenograft
After atraumatic extraction of the non-restorable tooth, Implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft and erythropoietin.
OTHERXenograft alone
After atraumatic extraction of the non-restorable tooth, implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft alone.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Inclusion criteria * Adult (≥18 years) with non-restorable maxillary teeth in the esthetic zone (upper right second premolar to upper left second premolar). * Intact with thin labial plate of bone (≤1mm). * The recipient site of the implant should be free from any pathological conditions. * Patients who are cooperative, motivated and hygiene conscious. * Appropriate crown height space to maintain favorable crown : implant ratio *
Exclusion criteria
* Systemic conditions/diseases that contraindicate surgery. * Patients who have any habits that might jeopardize the osseointegration process, such as current smokers. * Patients with parafunctional habits that produce overload on implant, such as bruxism and clenching. * Patients with periodontal disease. * Alcohol or drug abuse. * Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Buccal bone thickness. | 1 year follow up period | by Cone Beam Computed Tomography (CBCT) in mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Soft tissue thickness. | 1 year follow up period | will be measured by Endodontic spreader with rubber stopper in mm |
| The pink esthetic score (PES) | 1 year follow up period | by taking photographs |
| Success and survival criteria | 1 year follow up period | the absence of mobility, the absence of acute or chronic peri-implant infection, the absence of radiolucency around the implant, without pocket probing depth (PPD) ≧ 5 mm, and without vertical bone loss ≧ 1.5 mm in the first year. The cases will be defined as failure if it can't reach any one of the success criteria |
| Crestal bone loss | 1 year follow up period | will be measured by Cone Beam Computed Tomography (CBCT) in mm |
| Pain score | 1, 3, and 7 days | by using Visual analogue scale from (0-10) |
| Full-mouth plaque score | 1 year follow up period | According to presence (yes) or absence(No) of plaque |
| Bleeding on probing (BOP) | 1 year follow up period | According to presence (yes) or absence (No) of bleeding on probing |
Countries
Egypt
Contacts
Primary Contactkholoud El Deeb, Master degree holder
Outcome results
None listed