Individualized Intraoperative PEEP Following Alveolar Recruitment Maneuvres and Postoperative Respiratory Complications

The Influence of Individualized Intraoperative PEEP After Alveolar Recruitment Maneuvres on the Incidence of Postoperative Respiratory Complications Following Laparoscopic Abdominal Surgery. A Prospective Randomized Controlled Study

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06600386

Enrollment

Registered

2024-09-19

Start date

2024-09-30

Completion date

2025-02-01

Last updated

2025-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Respiratory Complications

Keywords

Alveolar Recruitment, Laparoscopy, Indvidualized PEEP

Brief summary

Patients ASA I-III, undergoing laparoscopic abdominal surgery will be randomly assigned, into one of two groups, namely group C-PEEP , that will be the control group ; and group I-PEEP, where alveolar recruitment maneuvres will take place in order to identify each patient's individualized optimal PEEP. All patients will receive a standardized anesthesia regimen. The lung ultrasound score will be evaluated in all patients in the PACU and then respiratory complications will be recorded on the 24th hour, 48th hour, 7th day and 30the day, postoperatively.

Interventions

OTHERAlveolar recruitement

PEEP after alveolar reruitment maneuvres

OTHERStandard PEEP

PEEP 5 cmH2O

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

ASA I-III Laparoscopic abdominal surgery

Exclusion criteria

Severe kidney dysfunction Severe hepatic dysfunction Severe respiratory disease Severe cardiac disease Severe neuromuscular disease BMI>30 Severe intraoperative hemorrage Severe intraoperative hemodynamic instability

Design outcomes

Primary

Measure	Time frame	Description
Respiratory complications	30 days	Postoperative complications (atelectasis, bronchospasm, pneumonia, respiratory failure, ARDS, prolonged mechanical ventilations, reintubation, pleural infusion, COPD exacerbation)

Secondary

Measure	Time frame	Description
SpO2	intraoperatively	—
PCO2	intraoperatively	—
PaO2/FiO2	intraoperatively	—
Cdyn	intraoperatively	—
Pplat	intraoperatively	—
MAP	intraoperatively	—
heart rate	intraoperatively	—
LUS score	Preoperatively and 30 minutes postoperatively	Ultrasonographic findigs
Ppeak	intraoperatively	—

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026