Blood Pressure, Hepatic Impairment, Oxidative Stress, Renal Disease
Conditions
Keywords
aged, postmenopause, bone mineral density, muscle strength
Brief summary
This study was conducted to investigate the effects of the intake of deep sea water prior to resistance training on blood pressure, oxidative stress and hepatic and renal variables in older women.
Detailed description
This study was a 32 weeks, double-blinded, randomized, placebo-controlled trial.
Interventions
DIETARY_SUPPLEMENTResistance training + deep sea water
A group that will perform a resistance training protocol with variable resistance and at the same time will receive a supplementation composed by deep sea water
DIETARY_SUPPLEMENTResistance training + Placebo
A group that will perform a resistance training protocol with variable resistance and at the same time will receive a placebo supplementation that have the same tasted than the deep sea water supplementation
DIETARY_SUPPLEMENTControl + deep sea water
A group that will maintain their usual live and at the same time will receive a supplementation composed by deep sea water
DIETARY_SUPPLEMENTControl + Placebo
A group that will maintain their usual live and at the same time will receive a placebo supplementation that have the same tasted than the deep sea water supplementation
Sponsors
University of Valencia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* (i) women aged ≥65years * (ii) able to climb 10 stairs without pause and walk 100m without a walker * (iii) score above 23 points in the mini-mental state examination * (iv) \<1h of physical activity per week throughout the six months before the study * (v) possess a medical certificate of aptitude to carry out physical activity
Exclusion criteria
Participants who had suffered: * (i) any type of musculoskeletal, cardiovascular, hepatic, renal, pulmonary, neurological, or neuromuscular injury or disorder and/or * (ii) taking any type of drug/supplement that may alter the results of the study (e.g., vitamin C, vitamin E, estrogens, beta-blockers, calcitonin, steroid hormones, etc.) * (iii) changes in body weight of more than 10% in the year prior to the study * (iv) have a severe hearing or visual impairment * (v) participate in another research project (within the last six months) involving an exercise, dietetic and/or pharmaceutical intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Malondialdehyde (MDA) | pre (week 0) and post (week 32) | Oxidative stress biomarker |
| Oxidized/reduced glutathione ratio (GSH/GSSG) | pre (week 0) and post (week 32) | Antioxidant enzyme |
| Interleukin-6 (IL-6) | pre (week 0) and post (week 32) | Inflammatory biomarker |
| Vitamin D | pre (week 0) and post (week 32) | Vitamin |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systolic blood pressure (SBP) | pre (week 0) and post (week 32) | Cardiovascular measure |
| Diastolic blood pressure (SBP) | pre (week 0) and post (week 32) | Cardiovascular measure |
| Up and Go test (UGT) | pre (week 0) and post (week 32) | Functional test |
| Age | pre (week 0) and post (week 32) | Sample demographic description |
| Glutamic-oxaloacetic transaminase (GOT) | pre (week 0) and post (week 32) | Hepatic biomarker |
| Weight | pre (week 0) and post (week 32) | Sample demographic description |
| Body mass index (BMI) | pre (week 0) and post (week 32) | Sample demographic description |
| Fat mass percentage (% fat mass) | pre (week 0) and post (week 32) | Sample demographic description |
| Height | pre (week 0) and post (week 32) | Sample demographic description |
| Glutamic-pyruvic transaminase (GPT) | pre (week 0) and post (week 32) | Hepatic biomarker |
| Gamma- glutamyl transpeptidase (GGT) | pre (week 0) and post (week 32) | Hepatic biomarker |
| Alkaline phosphatase enzyme (ALP) | pre (week 0) and post (week 32) | Hepatic biomarker |
Outcome results
None listed