Lung Cancer (NSCLC)
Conditions
Brief summary
The main aim of this study is to show that single photon emission tomography/Computer tomography (SPECT/CT) is a reliable examination to predict postoperative pulmonary function after segmentectomy, by comparing this predicted function to that measured at 1 and 6 months.
Detailed description
Lung cancer has a high prevalence, incidence and mortality in France and worldwide. Surgical treatment, possible only at an early stage, improves the prognosis of patients. In addition, the increasing accessibility of chest CT scans allows early detection and monitoring of small pulmonary nodules. As a result, more conservative surgical techniques are becoming increasingly important, including segmentectomy. Among patients for whom it is indicated, the preoperative assessment involves the evaluation of pulmonary function and the prediction of postoperative pulmonary function in order to validate the feasibility of surgery. To do this, several methods have been described: anatomical methods (segment counting), radiological imaging methods (CT, DECT, perfusion MRI), and nuclear imaging methods (planar perfusion and/or ventilation pulmonary scintigraphy, SPECT pulmonary perfusion scintigraphy), some of which are hybrid (SPECT/CT). The use of SPECT/CT to predict postoperative pulmonary function is routinely practiced, and its reliability, accuracy, and concordance with measured postoperative pulmonary function are well demonstrated for pneumectomy and lobectomy. For more conservative surgeries, the data in the literature remain uncertain. However, being able to predict pulmonary function is essential, both to justify the feasibility of the intervention, but also to target the most fragile patients and intensify their postoperative respiratory rehabilitation.
Interventions
OTHERlung scintigraphy
Use the SPECT/CT to predict pulmonary function
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* Person having received full information on the organization of the research and not having opposed the exploitation of this data * Patients having benefited from a single or multiple segmentectomy within the thoracic surgery department of the CHRU of Nancy during the period April 2021 to June 2023 * Patients having a complete pre-operative assessment (SPECT/CT, volumetric CT and EFR) * Patients having 2 post-operative assessments (respiratory functional exploration (EFR) at approximately 1 month post-operatively and 6 months post-operatively).
Exclusion criteria
* Patients who underwent more extensive surgery (lobectomy, pneumectomy) or less extensive surgery (wedge). * Patient who did not have a complete preoperative assessment (SPECT/CT or volumetric CT or missing respiratory functional exploration EFR). * Patient who did not have a complete postoperative assessment (missing respiratory functional exploration EFR at 6 months). NB: the absence of respiratory functional exploration EFR at 1 month postoperatively is not an exclusion criterion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To demonstrate that SPECT/CT is a reliable examination for predicting postoperative pulmonary function after segmentectomy, by comparing this predicted function to that measured at 1 and 6 months. | 7 months | Predicted postoperative pulmonary function using SPECT/CT (% perfusion participation of the removed segment(s)). Postoperative pulmonary function measured at 1 month Postoperative pulmonary function measured at 6 months |
Countries
France
Outcome results
None listed