Myocardial Bridging in Obstructive Hypertrophic Cardiomyopathy

The Association Between Myocardial Bridging and Atrial Fibrillation in Patients With Obstructive Hypertrophic Cardiomyopathy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06598995

Acronym

MB in oHCM

Enrollment

968

Registered

2024-09-19

Start date

2022-01-01

Completion date

2022-12-31

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation (AF), Myocardial Bridging, Obstructive Hypertrophic Cardiomyopathy

Brief summary

This study investigated the impact of myocardial bridging (MB) and its characteristics on preoperative atrial fibrillation and survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). We recruited 968 consecutive patients with oHCM who underwent myectomy at our institution between January 2015 and December 2019, including 144 patients with MB and 824 patients without MB. All patients received angiography before surgery. The diagnosis of preoperative atrial fibrillation was based on 12-lead electrocardiography, 24-hour Holter electrocardiography, or in-hospital electrocardiogram monitoring, which was extracted from patients' medical records. Surgical details and follow-up data were also collected.

Interventions

PROCEDURECoronary artery bypass grafting or unroofing

Patients had an MB with >75% compression degree would receive coronary artery bypass grafting, and those who underwent unroofing may had a depth of MB < 5mm (whether deal with these MB with a depth <5mm depends on the surgeon and the period time of patients received a surgery).

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

I(i) age ≥ 18 years and (ii) diagnosis of oHCM based on clinical and echocardiographic evaluation. \-

Exclusion criteria

(i) a history of heart surgery (ii) Patients who had coronary atherosclerosis or myocardial infraction; (iii) Patients who had no angiography records. \-

Design outcomes

Primary

Measure	Time frame	Description
All-cause death	One month after discharge	Any death occurred one month after discharge

Secondary

Measure	Time frame	Description
New-onset AF	One month after discharge.	Patients did not have AF before surgery, and AF occurred one month after discharge.
Composite endpoints	One month after discharge	Composite endpoints including all-cause death, new-onset AF, and readmission due to heart failure, stroke, and other cardiovascular events (such as myocardial infarction, arrhythmia).

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026