Serum Uromodulin and DN Systematic Review and Meta Analysis

Association of Serum Uromodulin and DKD a Systematic Review and Meta Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06596863

Enrollment

1774

Registered

2024-09-19

Start date

2024-05-01

Completion date

2024-05-30

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Nephropathies

Keywords

DKD, urimodulin

Brief summary

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Interventions

DIAGNOSTIC_TESTThe association of serum uromodulin with DN

Meta analysis of association of serum uromodulin with DKD

DIAGNOSTIC_TESTThe DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Studies were included if they met the following criteria: 1. serum level of uromodulin was determined; 2. the samples were enrolled from diabetic patients; 3. mean ± SD was reported for uromodulin between patients with and without DN; 4. the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion criteria

* Studies were excluded according to the following criteria: 1. duplicate studies; 2. review articles; 3. non original research articles; 4. studies with insufficient data to extract; 5. non-human research; 6. studies that determined urine level of uromodulin.

Design outcomes

Primary

Measure	Time frame	Description
Association of serum uromodulin with DKD: asystematic review and meta analysis	may, 2024	Evaluate the meta analysis of association of serum uromodulin in the 3 diabetic group comparing with each other and compare them to the control group and correlate these results with other kidney biomarker

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026