Intestinal Barrier Dysfunction
Conditions
Brief summary
The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?
Interventions
This study is an observational study and no intervention was performed on the patients.
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* men or women aged 18-80 years * expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection) * no preoperative intestinal barrier dysfunction * patients voluntarily participated in this study and signed an informed consent form.
Exclusion criteria
* Patients or their families refused to participate in this study * chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.) * history of antibiotic administration in the last 2 weeks * severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy * combined with severe hepatic, renal, and cardiac insufficiency patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| operating time | During surgery | Record the patient's surgical time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bowel habit | Preoperative | The patient was asked whether there were increased frequency of stool, changes in stool characteristics, constipation and other conditions before surgery |
| Surgical Procedures | During surgery | Record whether the patient underwent laparoscopic surgery or open surgery |
| hemorrhage | During surgery | Record the patient's intraoperative bleeding volume |
| Albumin | Preoperative and postoperative 24 hours | Record the patient's albumin levels before and 24 hours after surgery |
| Infection indicators | Preoperative and postoperative 24 hours | Record the values of PCT, IL-6, and CRP of patients before and 24 hours after surgery |
| nutritional status | Preoperative | Patients were assessed for risk of malnutrition by the Nutritional Risk Screening Scale (NRS-2002). A score of ≥3 indicated that the patient was at risk of malnutrition. |
| gender | Preoperative | — |
| Body Mass Index | Preoperative | — |
| diabetes | Preoperative | Record whether the patient has diabetes |
| enteral nutrition | The average observation time is 2 weeks after surgery. | Record the start time of enteral nutrition for patients after surgery. |
| Exhaust and defecation time | The average observation time is one week after surgery | Record the time of the patient's first exhaust and first bowel movement after surgery |
| age | Preoperative | — |
Contacts
Primary Contactweiming Li
Outcome results
None listed