Brain Tumor Adult, Posterior Fossa Tumor
Conditions
Keywords
Parkbench position, posterior fossa tumor, pulse pressure variation, fluid responsiveness
Brief summary
To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
Detailed description
Prospective RCT is conducted to compared the amount of fluid volume in adult patients undergoing posterior fossa surgery in park bench position.
Interventions
PROCEDUREPulse pressure variation
Fluid administration during posterior fossa surgery in the parkbench position is guided by the PPV value.
PROCEDURECentral venous pressure
Fluid administration during posterior fossa surgery in the parkbench position is guided by the CVP value.
Sponsors
Chiang Mai University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Outcome assessor received the anesthetic record form by unknown of the patient and group allocation.
Intervention model description
Two study groups are parallel according to the block of four randomization.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult patients aged 18 years and above 2. American Society of Anesthesiologists (ASA) I and II 3. Diagnosis of posterior fossa tumor requiring surgical resection in the park bench position, under general anesthesia at our hospital 4. Willing to participate in the study
Exclusion criteria
1. Arrhythmia 2. Significant cardiac diseases 3. Chronic obstructive airway disease 4. Elevated intra-abdominal pressure 5. Tumors prone to precipitate diabetes insipidus 6. Peripheral vascular disease 7. Pulmonary hypertension 8. Patients in sepsis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total intraoperative fluid administration volumes during surgery | during surgery | fluid and blood and blood volume transfusion during surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| vital signs | during surgery, the data will be recorded every 5 minutes throughout the procedure | blood pressure both systolic and diastolic pressure |
| time to extubation | 48 hours after surgery at the neurosurgical intensive care unit | to be able to succesfully extubated, count time period of using ventilator |
Other
| Measure | Time frame | Description |
|---|---|---|
| vasopressor requirement | during surgery and 48 hours at the neurosurgical ICU | type and amount of vasoactive medication |
| length of neurosurgical ICU stay | from date of randomization to the day of being discharged from ICU or up to 1 week after surgery, depended on which happen first | days of ICU stay |
Countries
Thailand
Outcome results
None listed