Aortic Stenosis
Conditions
Keywords
Aortic stenosis, Y-chromosome, Transforming growth factor-beta, Echocardiography
Brief summary
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
Interventions
DIAGNOSTIC_TESTBlood analysis for loss-of-Y chromosome
Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Sponsors
University of Virginia
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Aortic stenosis (valve area <1.5cm2)
Exclusion criteria
* Bicuspid aortic valve * History of radiation to chest * Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis * Active cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Loss of Y chromosome | 1 day | This is a cross-sectional case-control study where the outcome measure is the percentage of circulating cells that have loss-of-Y chromosome |
Countries
United States
Contacts
Primary ContactJonathan R Lindner, MD
Backup ContactBethany Gholson
Outcome results
None listed