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Harmonized and Pooled Database, Named PRIME.

Potentially Modifiable Ventilation Factors Associated With Outcome in Neurocritical Care vs Non-Neurocritical Care Patients - Rational and Protocol for a Patient-Level Analysis of PRoVENT, PRoVENT-iMiC and ENIO (PRIME)

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06592937
Acronym
PRIME
Enrollment
3270
Registered
2024-09-19
Start date
2024-01-01
Completion date
2024-07-26
Last updated
2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Invasive Ventilation

Keywords

ICU, Invasive ventilation, Respiratory support, Mortality

Brief summary

We merged the dataset of three large observational studies of invasive ventilation in critically ill patients.

Detailed description

PRIME contains the individual patient data of 3 large observational studies of ventilation, 'PRactice of VENTilation in critically ill patients without ARDS' (PRoVENT), 'PRactice of VENTilation in critically ill patients in Middle-income Countries' (PRoVENT-iMiC) and 'Extubation strategies and in neuro-intensive care unit patients and associations with outcomes' (ENIO).

Interventions

Invasive ventilation and respiratory support

Sponsors

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 99 Years

Inclusion criteria

All patients in the PRIME database are eligible for participation in the initial analysis presented here. We will exclude patients receiving ventilation fir another reason than acute brain injury.

Design outcomes

Primary

MeasureTime frameDescription
ICU moralityICU stay, anticipated average 15 daysany mortality occurred during ICU stay

Secondary

MeasureTime frameDescription
Mechanical PowerDuring the first 7 days of invasive ventilationAll variables or parameters recorded from the ventilator, when the patient is under mechanical ventilation, to calculate the mechanical power (calculated in Joule/minute)

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026