Pediatric and Adolescent Differentiated Thyroid Carcinoma, SEER Database Analysis
Conditions
Brief summary
This study aims to investigate the differences in clinical characteristics, causes of death, long-term survival, and surgical approaches between pediatric and adolescent follicular and papillary carcinoma by exploring data from the SEER database. The research is designed as a retrospective cohort study, primarily focused on collecting and comparing data to identify key disparities and outcomes between these two patient groups. It is anticipated that the findings will provide valuable insights into the management and prognosis of these cancers in younger populations, contributing to more targeted and effective treatment strategies.
Detailed description
This study is a retrospective cohort analysis aimed at elucidating the differences between pediatric and adolescent patients diagnosed with follicular and \[specific type\] carcinoma, utilizing data sourced from the SEER (Surveillance, Epidemiology, and End Results) database. The focus of the research is on a comprehensive comparison of various clinical aspects, including demographic characteristics, tumor features, treatment modalities, and survival outcomes. Key areas of investigation include the examination of clinical characteristics such as tumor size, location, and stage at diagnosis, as well as treatment approaches including surgery types and their impact on patient outcomes. Additionally, the study will assess the causes of death and overall survival rates among these young patients, aiming to identify any significant prognostic factors. By leveraging the robust and extensive data available in the SEER database, this study seeks to uncover critical insights into the management of follicular and \[specific type\] carcinoma in pediatric and adolescent populations. The findings are expected to contribute to the development of more tailored and effective therapeutic strategies, ultimately improving long-term survival and quality of life for affected patients.
Interventions
OTHERDifferent Pathological Types (FTC vs PTC)
Comprehensive Comparison of Pediatric and Adolescent Follicular Thyroid Carcinoma and Papillary Thyroid Carcinoma Patients
Sponsors
Dezhou Hospital Qilu Hospital of Shandong University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Pathologically confirmed diagnosis of Follicular Thyroid Carcinoma (FTC) or Papillary Thyroid Carcinoma (PTC). * Age range: Pediatric and adolescent patients (ages 1-18 years).
Exclusion criteria
* Patients with incomplete survival and clinical information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival (OS) | Up to 20 years post-diagnosis | Time from diagnosis until death from any cause. |
| T (Tumor) - Primary Tumor | Perioperatively/Periprocedurally | T describes the size and/or extent of the primary tumor, T values typically range from T0 to T4, where T0 indicates no evidence of a primary tumor (not detectable), and T4 indicates a large tumor that has significantly invaded surrounding tissues. |
| N (Nodes) - Regional Lymph Nodes | Perioperatively/Periprocedurally | The N staging will classify the extent of lymph node involvement as follows: N0 indicates no lymph node metastasis, N1a indicates metastasis to central compartment lymph nodes, and N1b indicates metastasis to lateral neck lymph nodes. |
| M (Metastasis) - Distant Metastasis | Within one month after the diagnosis of thyroid carcinoma | M describes whether cancer has spread to other parts of the body (distant metastasis). M values are usually M0 or M1, where M0 indicates no distant metastasis, and M1 indicates the presence of distant metastasis. |
Outcome results
None listed