Exploration of Gender Differences in Liver Aging

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06591897

Enrollment

Registered

2024-09-19

Start date

2024-09-27

Completion date

2027-09-20

Last updated

2024-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Population

Keywords

hepatocyte, liver function, sex differences

Brief summary

The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging. During aging, the volume, blood flow, metabolic capacity and regenerative capacity of the liver decrease. Liver function changes with age can lead to age-related systemic susceptibility diseases. Therefore, understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly population.On the other hand, gender factors also affect organ function, leading to differences in human aging and disease outcomes.At present, the omics research on liver aging is mainly based on tissue-level transcription, protein or metabolomics, and most of the conclusions are focused on hepatocytes. However, for other cell types and microenvironment interactions, people know little about the aging changes at the cellular levelBased on the current research status, this study aims to explore the gender differences in the process of liver aging, using emerging technologies such as the combination of single-cell multi-omics and spatial localization, to reveal the factors driving liver aging from a gender perspective, and to promote the development of accurate interventions for aging and aging-related diseases.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Liver function indicators are in the normal reference range. * Liver imaging examination showed normal.

Exclusion criteria

* Patients with previous liver-related diseases. * Subjects with important organ dysfunction / failure or other serious diseases ( myocardial infarction, malignant tumor, severe neurological or psychiatric history, severe infection, coagulation dysfunction, etc. ) * Moderate malnutrition ( BMI \< 17kg / m2 ) and severe anemia ( Hb \< 60g / L ). * Subjects and their families who disagreed with the study protocol.

Design outcomes

Primary

Measure	Time frame	Description
Molecular and cellular characteristics during liver aging	2027.08	Draw the map information of liver aging single cell precision, and clarify whether the effect of aging on liver cell types has gender differences.

Countries

China

Contacts

Primary Contactdaren Liu, MD, PhD

darenliu@zju.edu.cn15968179036

Outcome results