Prosthetic Joint Infection
Conditions
Brief summary
Determine if dietary protocatechuic acid (PCA) will affect health biomarkers in patient undergoing revision surgery for a knee prosthetic joint infection
Detailed description
Patients who are scheduled to undergo revision surgery for a knee prosthetic joint infection are given PCA prior to surgery for a time period determined by a previous pilot study. PCA is then post-operatively until anticoagulation is stopped, and then will be resumed for four years post revision surgery. Measurement of changes in glucose control, immunity, will be measured over the first 3 months post-revision, and the post-revision reinfection rate over the full 4 years will be compared to a cohort rate
Interventions
DIETARY_SUPPLEMENTOral PCA
PCA 1,000 mg BID until surgery, held until anticoagulation, and resumed at 1,000 mg daily for 4 years
Sponsors
Dr. Dean Reeves Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 3 weeks or more after total knee arthroplasty * One or more symptoms of infection, including redness, swelling, pain, increasing range of motion loss, fever, nausea, and loss of appetite. * WBC count of aspirate \>50,000 cells per μL
Exclusion criteria
* Not willing to undergo blood draw at 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in immunity factor CXCL9 from 0 to 3 months | 0 and 3 months |
| Change in HbA1c from 0 to 3 months | 0 and 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Reinfection rate after revision for prosthetic joint infection | 0 to 4 years |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORKenneth D Reeves, M.D.
K. Dean Reeves, M.D., P.A.
Outcome results
None listed