NAFLD, OSA, PCOS
Conditions
Brief summary
Complain of obstructive sleeping apnea and fatty liver is common in PCOS women so lifestyle changes are recommended
Detailed description
Forty obese PCOS men with obstructive sleeping apnea and compaint of fatty liver will participate in this trial . Group (study group) will contain twenty obese females with a complaint of PCOS and OSA and fatty liver. for eight weeks, these obese females will receive metformin tablet (thrice daily), program of low diet intake, and daily walking for 30 minutes. Group (control group) will contain twenty obese females with a complaint of PCOS and OSA and fatty liver . for eight weeks, these obese females will receive metformin tablet (thrice daily), program of low diet intake,
Interventions
BEHAVIORALdiet restriction and exercise
this group will contain twenty obese females with a complaint of NAFLD, PCOS and OSA. for eight weeks, these obese females will receive metformin tablet (thrice daily), program of low diet intake, and daily walking for 30 minutes
BEHAVIORALdiet restriction
this group will contain twenty obese females with a complaint of NAFLD, PCOS and OSA. for eight weeks, these obese females will receive metformin tablet (thrice daily) and program of low diet intake
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* forty women * women complaint PCOS * women complain obstructive sleep apnea * women are obese * women complain fatty liver
Exclusion criteria
* cardiac insult * renal insult * malignacy * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| aspartate transamianse | it will be assessed in serum after eight weeks |
Secondary
| Measure | Time frame |
|---|---|
| triglycerides | it will be assessed in serum after eight weeks |
| neck circumference | it will be assessed after eight weeks |
| waist circumference | it will be assessed after eight weeks |
| body mass index | it will be assessed after eight weeks |
| testesterone | it will be assessed in serum after eight weeks |
| alanine transaminase | it will be assessed in serum after eight weeks |
| apnea hyopnea index | it will be assessed after eight weeks |
| Epworth sleeping scale | it will be assessed after eight weeks |
| Dehydroepiandrosterone | it will be assessed in serum after eight weeks |
| waist hip ratio | it will be assessed after eight weeks |
| ratio of luteinizing hormone and follicle-stimulating hormone | it will be assessed after eight weeks |
Countries
Egypt
Outcome results
None listed