Acne Vulgaris
Conditions
Brief summary
compare the efficacy and safety of treating atrophic post acne scars with topical insulin versus Platelet rich Plasma PRP combined with fractional ablative Co2 laser
Detailed description
Acne vulgaris is a common cutaneous inflammatory disorder of the pilosebaceous unit, which runs a chronic course. The condition commonly manifests with papules, pustules, or nodules primarily on the face, although it can also affect the upper arms, trunk, and back. The pathogenesis of acne vulgaris involves the interaction of multiple factors that ultimately lead to the formation of its primary lesion, which is known as comedo. Because of its long duration and exposure to affected areas, acne is associated with a major deterioration in a patient's quality of life and well-being . Up to 95% of acne sufferers have some degree of acne scarring, with 30% reporting severe acne scarring. Scarring from acne is common when medical care is delayed or is not sufficient, although it can also occur even when treatment is adequate . About 90% of acne scars are related with collagen loss (atrophic scars), whereas the remaining 10- 20% show collagen gain (keloidal or hypertrophic scars). Resulting from the contraction of fibrous tissue, atrophic scars appear as depressions. Atrophic acne scars can be classified into three distinct types: boxcar, icepick, and rolling.
Interventions
COMBINATION_PRODUCTFractional CO2 laser assisted PDT
Comparative split face study: participants will be treated with fractional co2 laser on the whole face then applying topical insulin on the right side of the face and topical platelet rich plasma on the left side of the face.
Sponsors
Assiut University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
patients aged equal or more than 18 years with atrophic post acne scars.
Exclusion criteria
pregnancy and lactation. Hypertrophic scars. patients suffering from aggressive inflammatory acne. kidney or liver disease. active infection at site of lesion. patients use medications that reduce tissue healing during the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy and safety of treating atrophic post acne scars with topical insulin versus PRP combined with fractional ablative Co2 laser. | 5 months from the beginning of the treatment | Scar assessment will be made using the Goodman and Baron Qualitative and Quantitative scarring system at baseline and at each visit to evaluate the clinical improvement. |
Contacts
Primary ContactHager Gamal, mbBch
Backup ContactHanan Morsy, MD
Outcome results
None listed