Acute Stroke
Conditions
Keywords
Stroke, Body composition, Bioimpedancemetry, Temporal muscle, Sarcopenia
Brief summary
Body composition appears to be a prognostic factor for the severity and functional outcome of stroke patients. In this study the prognostic value of two bioimpedance parameters will be studied (skeletal mass index and phase angle) and two temporal muscle measurements (thickness and surface area) to predict the functional outcome of patients at discharge and at 6 months
Detailed description
A stroke commonly causes weakness and loss of independence. Predicting functional outcomes is a major challenge because it guides rehabilitation care or institutionalization choices. Various factors, including the extent of the initial deficit or the size of the lesion, have been shown to play a role in residual disability after stroke. Premorbid physiological status has been less studied in stroke. However, loss of muscle mass and premorbid strength are prognostic factors for poor short- and medium-term functional recovery. In this work, the body composition of patients in the acute phase of a stroke will be studied to determine whether its alteration is a poor prognostic factor in the short term (discharge from the initial hospitalization) and in the medium term (follow-up visit at 6 months). It will be studied using impedance analysis and morphological measurements on the temporal muscle. In a cohort study of hospitalized patients in the acute phase of a stroke, measurements using a bioimpedance meter (InBody BWA) will be performed to measure a skeletal mass index (SMI) and phase angle. The properties of the temporal muscle (thickness and surface) will also be measured at T1, within 72 first hours after the stroke. Clinical and morphological data will also be collected (weight, height, initial deficit, lesion volume). The aim of the work is to determine whether these body composition factors have an impact on the functional outcome of patients assessed at discharge and 6 months later. Functional assessment will be performed with modified Rankin score (mRS). It is hypothesized that all body composition factors studied will be factors independent of the short- and medium-term functional prognosis.
Interventions
DIAGNOSTIC_TESTModified Rankin scale
Acute stroke patients will undergo modified rankin scale
Sponsors
Centre Hospitalier Régional d'Orléans
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* volunteer stroke patients in acute phase * Age ≥ 18 years * Having had a brain MRI * Able to understand assessment guidelines * Not having objected to participate in the study after being duly informed
Exclusion criteria
* Person under tutorship or curatorship * Person under court protection * Persons deprived of their liberty * Pregnant or breastfeeding women * Have a pacemaker or defibrillator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| phase angle | 72 hours after stroke |
| thickness of temporal muscle | 72 hours after stroke |
| surface area of temporal muscle | 72 hours after stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Modified Rankin Scale (mRS) | Month 6 | The modified Rankin Scale is used to assess the disability of patients in the acute phase of stroke recovery. It consists of a single item, with 5 levels corresponding to no disability, mild disability, moderate disability, moderately severe disability and severe disability. |
| skeletal muscular Index | 72 hours after stroke | — |
Countries
France
Contacts
CONTACTMarc VERIN, PUPH
PRINCIPAL_INVESTIGATORMarc VERIN, PUPH
CHU ORLEANS
Outcome results
None listed