Allergy, Food Allergy
Conditions
Brief summary
The main objective of this study is to describe the distribution of reactogenic thresholds for pistachio. The secondary objectives are to 1) describe the clinical severity of allergic reactions to pistachio in an oral challenge test, 2) compare the reactogenic thresholds of pistachio and cashew nut on matched data and 3) evaluate predictive factors of a low reactogenic threshold
Detailed description
Nuts, including almonds, walnuts, cashews, pistachio and hazelnut, are among the food allergens most frequently involved in food allergies in children with an estimated prevalence. between 0.05 and 4.9%. According to data from the Allergo-Vigilance Network, peanuts and the group of nuts, led by cashews, are alone responsible for 51.4% of food anaphylaxis in children. The pistachio belongs to the same botanical family as the cashew nut (Anacardiumouest) and the mango (Mangifera indica): the anacardiaceae. Botanically, pistachio and cashew are closely related and can both be responsible for moderate to severe immediate allergic reactions. Furthermore, in a previous publication by the team, co-sensitization to pistachio was observed in 98% of children allergic to cashew nuts with only 34% confirmed allergic to pistachio. In the case of allergy to both anacardiaceae, in a small number of patients, the investigators reported a reactogenic threshold for pistachio greater than or equal to that for cashew nuts. To our knowledge, there is currently only one study that has evaluated the reactogenic threshold for pistachio, compared to other nuts.
Interventions
OTHERFood allergy
Threshold dose to pistachio
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients under 18 years of age who had a positive pistachio challenge test between January 2021 and December 2023, in the pediatric allergology unit of the Nancy CHRU.
Exclusion criteria
* Patients who had a questionable oral pistachio provocation test. * Patients who had a negative pistachio oral provocation test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Threshold dose to pistachio | in the 4 hours of monitoring | in mg of protein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Threshold dose to cashew | in the 4 hours of monitoring | in mg of proteins |
| Severity of the reaction during a positive pistachio oral provocation test | in the 4 hours of monitoring | defined by the COFAR (Consortium for Food Allergy Research) classification, from 1 to 5 and 1 is for mild symptoms |
Countries
France
Outcome results
None listed