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Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06588777
Enrollment
52
Registered
2024-09-19
Start date
2024-09-01
Completion date
2025-12-30
Last updated
2025-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy, Modified Thoracoabdominal Nerve Block, Quadratus Lumborum Block

Keywords

Laparoscopic cholecystectomy, modified thoracoabdominal nerve block, quadratus lumborum block

Brief summary

This study aims to compare the efficacy of using Ultrasound guided modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) versus quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy under general anesthesia.

Interventions

transversus abdominis, internal oblique, and external oblique muscles will be identified with a high-frequency (10 MHz) linear probe on the costochondral angle in the sagittal plane under ultrasound guidance at the 10th costal margin. A deep angle was given to the costochondral angle at the edge of the 10th costal margin with the probe in the sagittal direction to view the lower surface of the costal cartilage in the midline. A 22-G, 100-mm block needle will be inserted in the cranial direction using the in-plane technique and the needle tip will be moved to the posterior aspect of the 10th costal cartilage. It is noted that the needle tip never crossed the cranial edge of the 10th costal cartilage

PROCEDUREQuadratus lumborum block

using ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA) and a curved ultrasound probe (2.5-7.5 MHz). The probe will be placed in the mid-axillary line between the lower costal margin and the iliac crest in a transverse plane to view all abdominal layers. The probe will be moved towards the posterior axillary line, to reach a point where all three abdominal muscle layers merge to form aponeurosis. The aponeurosis will then be followed dorsally until the quadratus lumborum muscle is seen deep to transversalis fascia with its attachment to the transverse process of the L4 vertebral body. A 22 G, 100 mm, blunt, insulated nerve block needle will be inserted 1 cm medial to the probe and advanced using the in-plane technique with ultrasound real-time assessment. The injection site will be the junction of transversalis fascia and the anterolateral border of quadratus lumborum muscle

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
21 Years to 71 Years
Healthy volunteers
No

Inclusion criteria

* Adult patients aging ≥ 21 years to ≤ 70 of both sexes. * Patients undergoing Laparoscopic cholecystectomy surgeries. * ASA physical status classes I - II.

Exclusion criteria

* Patient's refusal of procedure or participation in the study. * ASA classes III or above. * Coagulopathy and bleeding disorders. * Evidence of Local skin infections at site of injection. * Body mass index \>40kg/m2 * A history of relevant local anesthetic allergy.

Design outcomes

Primary

MeasureTime frameDescription
Time to first Rescue Analgesia24 hours postoperativeIs to measure the first time to resque analgesia postoperative (24 hours)

Secondary

MeasureTime frame
The total requirements of rescue analgesia Meperidine (pethidine) over the first 24 hours postoperative24 hours postoperative
Heart rateat intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively
Blood pressureat intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively
Spo2 measuringat intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively

Countries

Egypt

Contacts

Primary ContactAhmed Hassan, Master
ahmedhassan199466@gmail.com01158195158

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026