Cannabis Use, Stress
Conditions
Brief summary
The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate. We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.
Interventions
OTHERWater Temperature Variation - WW
Participants are assigned to warm water temperature.
OTHERWater Temperature Variation - CW
Participants are assigned to cold water temperature and are video recorded.
Sponsors
National Institute on Drug Abuse (NIDA)
University of Colorado, Boulder
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 21-65 years of age * Endorsement of at least some use of cannabis for coping purposes (\>1 on CMMQ) * Regularly use flower cannabis products (i.e., ≥1x/week in the last 6 months) * Proficient in English language * At least occasional use of CBD+THC or CBD-dominant products (e.g., ≥1x/month)
Exclusion criteria
* Diagnosis or use of medications for substance use or psychotic disorders * Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs * Females cannot be pregnant or trying to become pregnant or nursing mothers * Not able to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Cortisol Levels | Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use | Cortisol levels are measured in blood. |
| Cannabis Used | Immediate Post-Use | Grams of product used is calculated. Product is measured before and after use to measure how much was used. |
| Blood Endocannabinoid Levels | Pre-Use/Pre-Water Task, 20 minutes Post-Use | Blood levels of AEA are measured. |
| Heart Rate | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use | Participant HR is measured via pulse oximeter. |
| Social Anxiety | Pre-Use/Pre-Water Task | Social Interaction Anxiety Scale (SIAS). 20 item survey, questions are answered on scale of 0 (not at all) to 4 (extremely), with higher scores indicating higher social anxiety. Questions are summed, with higher overall scores indicating higher social anxiety. |
| Inhibitory Control | Baseline | Go/No-go Task. Participants are asked to complete a cognitive task where they see the text Go or No go during different trials. When they see Go, they need to push a button within 2 seconds. When they see No-go, they need to make sure they do not press the button (for 2 seconds). This is a measure of impulsivity. |
| Stress | Pre-Use/Pre-Water Task | Stress Subscale of Depression and Anxiety Stress Scale measures stress. On scale from 0 (does not apply to me at all) to 3 (apply to me very much or most of the time). Higher scores indicate higher stress levels. |
| Blood cannabinoid levels | Pre-Use/Pre-Water Task, 20 minutes Post-Use | THC and CBD blood levels are measured. |
| Current Pain | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use | Internal scale/measure, measured from 0 (no pain) to 10 (worst pain imaginable). Participants report current pain on this self-report scale. |
| Mood | Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use | Profile of Mood States (POMS). Focus on the stress, anxiety, tension, and relaxation questions (combined for a tension/anxiety subscale). Questions are on a scale 1 (not at all) to 5 (extremely). Scores are summed, with higher scores indicating more tension/anxiety. |
Countries
United States
Contacts
Primary ContactCarillon Skrzynski, PhD
Outcome results
None listed