Parkinson Disease
Conditions
Keywords
Cognitive-motor training, Executive function, Gait, Electroencephalography
Brief summary
Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.
Interventions
Cognitive-motor training is that cognitive tasks incorporated into motor tasks.
OTHERConventional physiotherapy
Conventional physiotherapy includes stretching, ROM exercise, strengthening exercise, and eye-hand coordination.
Sponsors
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnoses of idiopathic Parkinson disease * Stable dopaminergic medicine ≥ 2 weeks * Able to walk 10 meters without aid * Mini-Mental Status Examination ≥ 24 points * No uncorrected visual or auditory disorders * Education at least junior high school * No other disease may affect balance
Exclusion criteria
* Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders * History of brain surgery (e.g. deep brain stimulation)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Trail making test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Trail making test contain part A and part B. Faster completing the test indicates better executive function. |
| Digit span test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function. |
| Event-related potential - N2 | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Measure event-related potential through electroencephalography under single-task and dual-task paradigm. |
| Event-related potential - P300 | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Measure event-related potential through electroencephalography under single-task and dual-task paradigm. |
| Go/Nogo test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Behavioral test during measuring electroencephalography. |
| Gait variability | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100% |
| Gait speed | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure gait speed |
| Step length | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure step length |
| Step width | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure step width |
| Single support time | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure single support time |
| Double support time | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure double support time |
| Frontal Assessment Battery | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | The score ranged from 0 to 18. Higher scores show better executive function. |
| Stroop color and word test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Record numbers of corrected color words which the subject responds within 45 sec. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Montreal Cognitive Assessment | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Montreal Cognitive Assessment ranges from 0 to 30. Higher scores reflect better cognitive performances. |
| Timed up and go test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Record time of performing timed up and go test |
| Parkinson Disease Questionnaire | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Parkinson Disease Questionnaire assess quality of life in people with Parkinson disease. Lower scores reflect higher quality of life. |
| Mini-Balance Evaluation Systems Test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Mini-Balance Evaluation Systems Test scores range from 0 to 28. Higher scores indicate better balance ability. |
Countries
Taiwan
Contacts
Primary ContactYea-Ru Yang, PhD
Outcome results
None listed