Cardiac Arrest, Out-Of-Hospital
Conditions
Keywords
Biomarkers, Brain injury, Inflammation, Dementia
Brief summary
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.
Detailed description
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion. Samples will be analysed in batch for biomarkers of brain injury, inflammation etc. Primary outcome is functional outcome (modified Rankin Scale 4-6) at six months after cardiac arrest. Secondary outcomes are neurocognitive function according to the Montreal Cognitive Assessment (MoCA), Symbol Digits Modalities Test (SDMT).
Interventions
None listed
Sponsors
Region Skane
Lund University
University of Helsinki
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Survivors of out-of-cardiac arrest who participate in the extended follow-up study of the STEPCARE trial at selected sites only
Exclusion criteria
* Patients not participating in the extended follow-up at participating sites
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional outcome | 6 months | Modified Rankin Scale 4-6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurocognitive outcomes | 6 months | Montreal Cognitive Assessment |
Countries
Sweden
Outcome results
None listed