Cancer, Treatment-Related, Late Effect, Semen Analysis
Conditions
Keywords
cancer treatment, testicular function, semen quality, cancer survivors
Brief summary
Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.
Detailed description
This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old, currently \> 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.
Interventions
OTHERHormonal profile
Blood for FSH, LH, testosterone
OTHERSemen analysis
Semen analysis
OTHERQuestionnaire
The European Male Ageing Study (EMAS) questionnaire
Sponsors
Queen Mary Hospital, Hong Kong
Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Children's Hospital
The University of Hong Kong
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old. * \> 18 years old to 50 years old * Cancer in remission for at least 2 years
Exclusion criteria
* Unable to ejaculate by masturbation to provide semen samples * Cryptorchidism, testicular cancer, history of vasectomy * On testosterone replacement therapy * Refusal to join the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm concentration | up to 3 months | Sperm concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Semen parameters | up to 3 months | Based on the WHO criteria |
Other
| Measure | Time frame | Description |
|---|---|---|
| Testicular volume | up to 3 months | Measured with the Prader orchidometer |
| Hormonal profile | up to 3 months | Serum level of testosterone |
Countries
China
Contacts
Primary ContactJennifer Ko
Outcome results
None listed