Epidemiology, Gastroesophageal Reflux Disease, Risk Factors
Conditions
Keywords
Gastroesophageal reflux diseases, Barrett esophageal
Brief summary
Gastroesophageal Reflux Disease (GERD) is a condition characterized by the reflux of gastric and duodenal contents into the esophagus, primarily manifested by symptoms such as acid regurgitation and heartburn. GERD significantly affects patients' daily lives and health-related quality of life. Prolonged gastroesophageal reflux can lead to repeated irritation of the esophageal mucosa by gastric acid and acidic gastric contents, resulting in the replacement of normal squamous epithelium in the lower esophagus with metaplastic columnar epithelium. This pathological change, known as Barrett's Esophagus (BE), is considered a precancerous lesion for esophageal adenocarcinoma.
Detailed description
GERD is a common gastrointestinal disorder with numerous risk factors that negatively impact patients' quality of life. Abnormal psychological conditions may influence various aspects of GERD, including its onset, diagnosis, treatment, and prognosis. The incidence and risk factors of GERD vary in different countries or regions. Currently, there is a lack of unified national epidemiological data on GERD in China. Conducting epidemiological studies on GERD in China to identify risk factors and develop prevention and treatment measures tailored to the country's or specific regions' circumstances is crucial for reducing the incidence of GERD and improving patients' quality of life. In the context of the modern biomedical model of "biopsychosocial" health, actively researching the psychological conditions of patients, while also addressing their physical ailments and providing psychological treatment, emphasizes holistic care. This approach may comprehensively alleviate disease symptoms and enhance quality of life, potentially leading to new breakthroughs in the treatment of GERD. Based on this, a specialized cohort for gastroesophageal reflux disease will be established, along with multicenter epidemiological and clinical research in the Xiamen area. This initiative will help clarify the etiology of GERD and provide firsthand resources for evidence-based prevention and treatment.
Interventions
OTHERNo intervention
This concerns a natural history study. No interventions will be used.
Sponsors
Zhongshan Hospital (Xiamen), Fudan University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
16 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* All patients had experienced typical reflux symptoms, i.e., mild heartburn and/or regurgitation symptoms, for at least 2 days per week or moderate/severe reflux symptoms for more than 1 day per week during the previous 3 months and had upper endoscopy examinations in the previous month. * Cooperate with the questionnaire survey. * Volunteer and sign the informed consent form. * Permanent residents in Xiamen.
Exclusion criteria
* Malignant tumor. * Partial or total gastrectomy. * Failing to cooperate with the investigation because of the factors such as education level and language intelligence disorder, etc. * Patients with severe heart, lung, kidney, liver, blood, nerve, endocrine and mental system diseases. * Patients with mental retardation, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The prevalence of GERD in Xiamen city | 3 months. | Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder in the world. In this study, we will study the incidence of GERD in Xiamen city. |
| The percentage of reflux esophagitis | 3 months. | The percentage of participants diagnosed with reflux esophagitis using endoscopy among patients with baseline symptoms. |
| The percentage of Barrett esophagus | 3 months. | The percentage of paticipants diagnosed with pathological Barrett esophagus using endoscopy monitoring among patients with baseline symptom in gastroenterology department will be calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The life quality of GERD patients who were diagnosed by endoscopy | 3 months. | The life quality of GERD patients with different main symptoms before PPI test will be measured via the 50-item short form health survey , in which higher scores mean a better quality of life. |
| The sensitivity of GERD-Q for diagnosis of GERD | 3 months. | The sensitivity of GERD-Q for the diagnosis of GERD in patients with typical or atypical reflux symptoms will be calculated. The presence of reflux esophagitis on upper endoscopy and/or pathological acid reflux on 24-hour pH monitoring are considered as the gold standard for the diagnosis of GERD. |
| The specificity of GERD-Q for diagnosis of GERD | 3 months. | The specificity of GERD-Q for the diagnosis of GERD in patients with typical or atypical reflux symptoms will be calculated. The presence of reflux esophagitis on upper endoscopy and/or pathological acid reflux on 24-hour pH monitoring are considered as the gold standard for the diagnosis of GERD. |
Countries
China
Contacts
STUDY_CHAIRWei Jiang, Doctor
Zhongshan Hospital (Xiamen), Fudan University
Outcome results
None listed