Diabetes Mellitus, Pancreatic Cancer, Surgery
Conditions
Keywords
Pancreatic Cancer, Surgery, Diabetes Mellitus, Risk factor
Brief summary
The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after pancreatic cancer of different etiologies the same? 2. Are alterations in endocrine and exdocrine secretory function in patients with pancreatic surgery associated with all-round outcomes? All patients with pancreatic surgery have been given the standardized treatment for the condition. The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes.
Detailed description
Investigators will prospectively collect data from patients with pancreatic cancer after surgery in participant centers.
Interventions
DIAGNOSTIC_TESTAll enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.
All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.
Sponsors
Shanghai Changzheng Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. male or female Chinese subjects; 2. Age ≥ 18 years; 3. patients with pancreatic cancer who are proposed to undergo pancreatectomy by pancreaticobiliary surgery at our hospital; 4. those who voluntarily completed the Pancreatobiliary Surgery Cohort Study and signed the informed consent; 5. those who have completed and banked serum and pathological specimens at our hospital. \-
Exclusion criteria
1\. those with a previous history of comorbid diabetes mellitus or pre-diabetes mellitus, or preoperative HbA1C ≥ 6.0% or fasting blood glucose ≥ 6.1 mmol/l; 2. those with positive islet-associated antibodies 3. those with the presence of medications, endocrine disease exposures that can lead to a risk of secondary diabetes; 4. pregnant or nursing women; 5. Cognitive impairment or other reasons for failing to sign the informed consent form. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants Who developed glucose metabolic disorders(pre-diabetes and diabetes mellitus) | From enrollment to five years after the end of the surgery | The diagnosis of glucose disorders should be made applying criteria of the American Diabetes Association. |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival | From enrollment to five years after the end of the surgery |
| Disease-Free Survival | From enrollment to five years after the end of the surgery |
Countries
China
Contacts
Primary ContactTuo Li, Doctor
Outcome results
None listed