IVF
Conditions
Brief summary
To find out if the percentage of endometrial compaction is correlated to clinical pregnancy rate in down regulated frozen embryo transfer cycle. Endometrial compaction is the change in endometrial thickness between the end of the estrogen only phase and the day of embryo transfer. In concept, the compaction of the endometrium after progesterone initiation indicates that the endometrium is responsive to progesterone and could therefore be used as a proxy for endometrial receptivity predictability of FET cycle outcome
Interventions
DRUGObservational
To observe if endometrial compaction ≥ 5% in down regulated FET cycles increases clinical pregnancy rate.
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Women undergoing down regulated cycles frozen embryo transfer. * Women at age group 20-35 years old. * Day 5 embryos will be transferred.
Exclusion criteria
* Chromosomal abnormality in either partner (As this could lead to cycle cancellation). * Uterine malformation or any intrauterine condition affecting the pregnancy outcomes of FET, such as endometrial polyps, uterine cavity adhesion, history of endometrial tuberculosis, hydrosalpinx with a reflux into uterine cavity (As the might not be candidates for IVF cycle till correction). * Recurrent implantation failure, defined as 2 or more previous failed trials (Other confounding factors might of present which could affect the results). * Cycles of patients with persistent endometrial thickness \<7mm during treatment protocol (Due to cycled cancelation).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 3-4 wks after ET | Clinical pregnancy rate, determined by visualizing a viable embryo within the uterine cavity by ultrasound 3-4 weeks after ET, in patients with endometrial compaction in down regulated FET cycles in comparison to non endometrial compaction. |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of change of endometrial thickness between the end of estrogen administration only phase and the day of embryo transfer. | 3-4 wks after ET |
| Chemical pregnancy rates, detected by positive hCG test in the absence of pregnancy findings on TVUS | 3-4 wks after ET |
| Number of estrogen administration days | 10 days before ET |
Countries
Egypt
Outcome results
None listed